TkA02G427350 | RubberDandelionOmics

基因概览

TkA02G427350

当前版本: TK1151 染色体: Chr02 坐标: 108577950-108581061 链方向: + 类型: protein_coding

cDNA / CDS / 蛋白序列

可用序列下载 CDS FASTA 蛋白 FASTA cDNA FASTA

cDNA

1296 bp · TkA02G427350|TK1151|cDNA

ATGTCGGAAGCTCCGGCTTCAAACCGCGAAGAAGCGCCACCACCACCATCTACATCGGCTGCCGCCGGACCAAGACGACTGATCCCTTATCCAATGAGACGGAAGTTTTCTTTATATTCAACAAAACCTCCGTTCATTCCTACTGATGATTACCATCGCTTTTTCACTGGAAATGGTGACAAGAGAATTGTCAGCACCGCCGATCAGGAGGCTGATATTGTTATCGTTAGATCGCCGTCAGTGAAGAGAAAACTTGGAAC...

CDS

下载 CDS FASTA

1296 bp · TkA02G427350|TK1151|CDS

ATGTCGGAAGCTCCGGCTTCAAACCGCGAAGAAGCGCCACCACCACCATCTACATCGGCTGCCGCCGGACCAAGACGACTGATCCCTTATCCAATGAGACGGAAGTTTTCTTTATATTCAACAAAACCTCCGTTCATTCCTACTGATGATTACCATCGCTTTTTCACTGGAAATGGTGACAAGAGAATTGTCAGCACCGCCGATCAGGAGGCTGATATTGTTATCGTTAGATCGCCGTCAGTGAAGAGAAAACTTGGAAC...

蛋白

下载蛋白 FASTA

431 aa · TkA02G427350|TK1151|PROTEIN

MSEAPASNREEAPPPPSTSAAAGPRRLIPYPMRRKFSLYSTKPPFIPTDDYHRFFTGNGDKRIVSTADQEADIVIVRSPSVKRKLGTSHNEVASNEWASPGHASTITSPVCTPVSAKGGKVNSRSTKSNKPVPQTPLQISGSPSPVTRYDNSLGHLTKRFINLITHAEDGVVDLNKAAETLEVPKRRIYDITNVLEGIGLIEKKCKNVIRWKGLDSSKPEELEDDVTLLQAEVKRLSMEEQRLDESTTEMEERMRDLSED...

上下游序列下载

序列方向与下载说明

上游/下游最大各 10000 bp。负链基因会自动反向互补，使最终 FASTA 为转录方向 5′→3′。

多版本 ID 对照

输入 ID	`TkA02G427350`
TK1151 ID	TkA02G427350
OH-1004 ID	LXL04_014416
关系 / 置信度	跨参考版本对应关系 / Probable
蛋白一致性 (%)	93.100
蛋白覆盖度 (%)	TK1151 100.000 / OH-1004 100.000 覆盖度与证据说明覆盖度为最高分比对片段的序列跨度占代表蛋白长度的比例。同源匹配不等同于功能验证。
版本	TK1151 / GWHBCHF00000000

查看完整 ID 对照表

SNP / Indel 变异与样本携带情况CRA009020 · TK1151

展开后加载该基因的变异记录。

基因基本信息与功能注释

基因 ID TkA02G427350

位置 Chr02:108577950-108581061 (+)

描述 Similar to E2FA: Transcription factor E2FA

拟南芥 / 水稻参考基因与文献

下载当前基因文献

拟南芥

参考基因 ID	可能功能	对应论文 / DOI
`At2g36010`	转录激活剂，通过 E2 识别位点 5'-TTTC[CG]CGC-3' 与 DP 蛋白协同结合 DNA，该位点存在于许多基因的启动子区域，其产物涉及细胞周期调节或 DNA 复制。	Arabidopsis E2F1 binds a sequence present in the promoter of S-phase-regulated gene AtCDC6 and is a member of a multigene family with differential activities.2001 · DOI: 10.1023/a:1011848528377 The E2F family of transcription factors from Arabidopsis thaliana. Novel and conserved components of the retinoblastoma/E2F pathway in plants.2002 · DOI: 10.1074/jbc.m110616200 Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor.2002 · DOI: 10.1093/emboj/21.6.1360 Interaction of the Arabidopsis E2F and DP proteins confers their concomitant nuclear translocation and transactivation.2002 · DOI: 10.1104/pp.010642 Constitutive E2F expression in tobacco plants exhibits altered cell cycle control and morphological change in a cell type-specific manner.2003 · DOI: 10.1104/pp.103.025080 The plant-specific cyclin-dependent kinase CDKB1;1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis.2004 · DOI: 10.1105/tpc.104.024398 Interplay between Arabidopsis activating factors E2Fb and E2Fa in cell cycle progression and development.2006 · DOI: 10.1104/pp.106.077990 Dissecting regulatory pathways of G1/S control in Arabidopsis: common and distinct targets of CYCD3;1, E2Fa and E2Fc.2009 · DOI: 10.1007/s11103-009-9527-5
`At5g22220`	可能结合靶基因启动子，调控细胞周期及 DNA 复制相关基因的转录。	Arabidopsis E2F1 binds a sequence present in the promoter of S-phase-regulated gene AtCDC6 and is a member of a multigene family with differential activities.2001 · DOI: 10.1023/a:1011848528377 The E2F family of transcription factors from Arabidopsis thaliana. Novel and conserved components of the retinoblastoma/E2F pathway in plants.2002 · DOI: 10.1074/jbc.m110616200 Interaction of the Arabidopsis E2F and DP proteins confers their concomitant nuclear translocation and transactivation.2002 · DOI: 10.1104/pp.010642 The role of the Arabidopsis E2FB transcription factor in regulating auxin-dependent cell division.2005 · DOI: 10.1105/tpc.105.033761 Interplay between Arabidopsis activating factors E2Fb and E2Fa in cell cycle progression and development.2006 · DOI: 10.1104/pp.106.077990
`At1g47870`	参与转录抑制。	The E2F family of transcription factors from Arabidopsis thaliana. Novel and conserved components of the retinoblastoma/E2F pathway in plants.2002 · DOI: 10.1074/jbc.m110616200 Interaction of the Arabidopsis E2F and DP proteins confers their concomitant nuclear translocation and transactivation.2002 · DOI: 10.1104/pp.010642 Arabidopsis E2Fc functions in cell division and is degraded by the ubiquitin-SCF(AtSKP2) pathway in response to light.2002 · DOI: 10.1105/tpc.006791 The balance between cell division and endoreplication depends on E2FC-DPB, transcription factors regulated by the ubiquitin-SCFSKP2A pathway in Arabidopsis.2006 · DOI: 10.1105/tpc.105.039651 Dissecting regulatory pathways of G1/S control in Arabidopsis: common and distinct targets of CYCD3;1, E2Fa and E2Fc.2009 · DOI: 10.1007/s11103-009-9527-5

水稻

当前来源表未检出该物种的同源命中。

功能注释来源

查看注释来源

功能注释来源：OH1004 · LXL04_014416 · GCA_047496595.1_OSU_TarKok_2.0。此处为经 ID 对照查得的 OH1004 注释；下方拟南芥/水稻同源表使用当前查询参考的独立蛋白比对。

GO 注释（OH1004 来源）

GO:0000082 G1/S transition of mitotic cell cycle 生物过程

GO:0000902 cell morphogenesis 生物过程

GO:0006351 DNA-templated transcription 生物过程

GO:0006355 regulation of DNA-templated transcription 生物过程

GO:0006357 regulation of transcription by RNA polymerase II 生物过程

GO:0006606 protein import into nucleus 生物过程

GO:0008284 positive regulation of cell population proliferation 生物过程

GO:0009733 response to auxin 生物过程

GO:0010090 trichome morphogenesis 生物过程

GO:0012501 programmed cell death 生物过程

GO:0019760 glucosinolate metabolic process 生物过程

GO:0030030 cell projection organization 生物过程

KEGG 基因交叉引用

ath:AT1G47870

ath:AT2G36010

ath:AT5G22220

mmu:13557

mmu:13559

以下为同源蛋白关联的 KEGG 基因编号，不代表本基因已获得通路功能验证。

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基因表达

查看该基因在不同研究、组织与处理条件下的表达量。表达结果按研究与计量单位分别展示。

查看该基因的表达量

数据来源与对应关系说明

表达数据来自公开转录组研究；参考版本、样本信息和表达单位见查询结果。跨参考版本的对应关系不唯一时，不自动选择表达记录；缺失值不视为表达量为零。

亚细胞定位 Top 5

以下为计算预测或同源注释，不能替代定位实验。

细胞核0.940

排名 1 · TkA02G427350 · TK1151

细胞质0.200

排名 2 · TkA02G427350 · TK1151

线粒体0.026

排名 3 · TkA02G427350 · TK1151

细胞膜0.017

排名 4 · TkA02G427350 · TK1151

高尔基体0.009

排名 5 · TkA02G427350 · TK1151

LocPro · 直接预测 · 计算预测，非定位实验结果

进入亚细胞定位查询

预测功能结构域

结构域结果来自 Pfam-A/HMMER；位置为对应蛋白序列上的氨基酸坐标。

PF15721ANXA2R10-115 aa

PF16526CLZ146-182 aa

PF02319WHD_E2F_TDP150-213 aa

PF10007DUF2250158-210 aa

PF16221HTH_47159-202 aa

PF01978TrmB174-206 aa

PF16526CLZ218-255 aa

PF06005ZapB220-263 aa

基因 ID	结构域编号	结构域名称	起始 aa	终止 aa	E 值	评分
TkA02G427350	`PF15721`	ANXA2R	10	115	0.28	12.3
TkA02G427350	`PF16526`	CLZ	146	182	0.021	15.9
TkA02G427350	`PF02319`	WHD_E2F_TDP	150	213	1.4e-26	92.7
TkA02G427350	`PF10007`	DUF2250	158	210	0.014	16.2
TkA02G427350	`PF16221`	HTH_47	159	202	0.11	12.8
TkA02G427350	`PF01978`	TrmB	174	206	0.0035	17.9
TkA02G427350	`PF16526`	CLZ	218	255	0.021	15.9
TkA02G427350	`PF06005`	ZapB	220	263	0.082	14.1
TkA02G427350	`PF28175`	T4SS_LegC2C7	220	269	0.28	10.7
TkA02G427350	`PF16421`	E2F_CC-MB	229	329	1.4e-32	112.4
TkA02G427350	`PF07160`	SKA1	229	277	0.072	13.6
TkA02G427350	`PF15721`	ANXA2R	347	412	0.28	12.3

拟南芥 / 水稻蛋白同源

仅展示拟南芥和水稻；Swiss-Prot 为人工审校条目，TrEMBL 为补充序列候选。同源相似性不等同于实验验证。

下载当前结果

蛋白	物种	描述	一致性	数据库	置信等级
`Q9FNY0`	拟南芥	sp\|Q9FNY0\|E2FA_ARATH Transcription factor E2FA	50.600%	Swiss-Prot	高置信
`Q9FV71`	拟南芥	sp\|Q9FV71\|E2FB_ARATH Transcription factor E2FB	48.000%	Swiss-Prot	中等置信
`Q9FV70`	拟南芥	sp\|Q9FV70\|E2FC_ARATH Transcription factor E2FC	50.200%	Swiss-Prot	中等置信

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