query	query_gene_id	query_protein_id	source_reference	hit_rank	swissprot_acc	swissprot_entry	database_section	target_gene_id	description	organism	homolog_gene_name	percent_identity	alignment_length	query_coverage	evalue	bitscore	confidence	evidence_type	source_db	reference_gene_id	reference_function_zh	reference_function_en	reference_papers_json
LXL04_002378	gene-LXL04_002378	KAL4589471.1	OH-1004	2	Q9S7U9	M2K2_ARATH	Swiss-Prot		Mitogen-activated protein kinase kinase 2 OS=Arabidopsis thaliana OX=3702 GN=MKK2 PE=1 SV=2	Arabidopsis thaliana	MKK2	68.362	354	100.0	0.0	523.0	strong_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	At4g29810	MEKK1、MKK1/MKK2 和 MPK4 在信号通路中发挥作用，调节响应生物和非生物胁迫的基因表达，并通过负向调节先天免疫在病原体防御中发挥重要作用。	MEKK1, MKK1/MKK2 and MPK4 function in a signaling pathway that modulates the expression of genes responding to biotic and abiotic stresses and also plays an important role in pathogen defense by negatively regulating innate immunity.	"[{""pmid"":""15225555"",""title"":""The MKK2 pathway mediates cold and salt stress signaling in Arabidopsis."",""doi"":""10.1016/j.molcel.2004.06.023"",""url"":""https://pubmed.ncbi.nlm.nih.gov/15225555/"",""year"":""2004"",""journal"":""Molecular cell"",""authors"":""Teige M, Scheikl E, Eulgem T, Dóczi R, Ichimura K, Shinozaki K, Dangl JL, Hirt H."",""matched_aliases"":[""MKK2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""17506336"",""title"":""The MAP kinase kinase MKK2 affects disease resistance in Arabidopsis."",""doi"":""10.1094/mpmi-20-5-0589"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17506336/"",""year"":""2007"",""journal"":""Molecular plant-microbe interactions : MPMI"",""authors"":""Brader G, Djamei A, Teige M, Palva ET, Hirt H."",""matched_aliases"":[""MKK2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18599650"",""title"":""Arabidopsis mitogen-activated protein kinase kinases MKK1 and MKK2 have overlapping functions in defense signaling mediated by MEKK1, MPK4, and MKS1."",""doi"":""10.1104/pp.108.120006"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18599650/"",""year"":""2008"",""journal"":""Plant physiology"",""authors"":""Qiu JL, Zhou L, Yun BW, Nielsen HB, Fiil BK, Petersen K, Mackinlay J, Loake GJ, Mundy J, Morris PC."",""matched_aliases"":[""MKK2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
LXL04_002378	gene-LXL04_002378	KAL4589471.1	OH-1004	3	Q94A06	M2K1_ARATH	Swiss-Prot		Mitogen-activated protein kinase kinase 1 OS=Arabidopsis thaliana OX=3702 GN=MKK1 PE=1 SV=2	Arabidopsis thaliana	MKK1	64.789	355	99.435	7.67e-168	474.0	strong_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	At4g26070	MEKK1、MKK1/MKK2 和 MPK4/MPK6 在信号通路中发挥作用，调节响应生物和非生物胁迫的基因表达，并通过负向调节先天免疫在病原体防御中发挥重要作用。	MEKK1, MKK1/MKK2 and MPK4/MPK6 function in a signaling pathway that modulates the expression of genes responding to biotic and abiotic stresses and also plays an important role in pathogen defense by negatively regulating innate immunity.	"[{""pmid"":""10759527"",""title"":""ATMPK4, an Arabidopsis homolog of mitogen-activated protein kinase, is activated in vitro by AtMEK1 through threonine phosphorylation."",""doi"":""10.1104/pp.122.4.1301"",""url"":""https://pubmed.ncbi.nlm.nih.gov/10759527/"",""year"":""2000"",""journal"":""Plant physiology"",""authors"":""Huang Y, Li H, Gupta R, Morris PC, Luan S, Kieber JJ."",""matched_aliases"":[""AtMEK1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""17059410"",""title"":""The Arabidopsis MAP kinase kinase MKK1 participates in defence responses to the bacterial elicitor flagellin."",""doi"":""10.1111/j.1365-313x.2006.02888.x"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17059410/"",""year"":""2006"",""journal"":""The Plant journal : for cell and molecular biology"",""authors"":""Mészáros T, Helfer A, Hatzimasoura E, Magyar Z, Serazetdinova L, Rios G, Bardóczy V, Teige M, Koncz C, Peck S, Bögre L."",""matched_aliases"":[""MKK1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""17728292"",""title"":""AtMEK1 mediates stress-induced gene expression of CAT1 catalase by triggering H2O2 production in Arabidopsis."",""doi"":""10.1093/jxb/erm144"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17728292/"",""year"":""2007"",""journal"":""Journal of experimental botany"",""authors"":""Xing Y, Jia W, Zhang J."",""matched_aliases"":[""AtMEK1"",""MEK1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18248592"",""title"":""AtMKK1 mediates ABA-induced CAT1 expression and H2O2 production via AtMPK6-coupled signaling in Arabidopsis."",""doi"":""10.1111/j.1365-313x.2008.03433.x"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18248592/"",""year"":""2008"",""journal"":""The Plant journal : for cell and molecular biology"",""authors"":""Xing Y, Jia W, Zhang J."",""matched_aliases"":[""AtMKK1"",""MKK1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18599650"",""title"":""Arabidopsis mitogen-activated protein kinase kinases MKK1 and MKK2 have overlapping functions in defense signaling mediated by MEKK1, MPK4, and MKS1."",""doi"":""10.1104/pp.108.120006"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18599650/"",""year"":""2008"",""journal"":""Plant physiology"",""authors"":""Qiu JL, Zhou L, Yun BW, Nielsen HB, Fiil BK, Petersen K, Mackinlay J, Loake GJ, Mundy J, Morris PC."",""matched_aliases"":[""MKK1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""19484493"",""title"":""AtMKK1 and AtMPK6 are involved in abscisic acid and sugar signaling in Arabidopsis seed germination."",""doi"":""10.1007/s11103-009-9503-0"",""url"":""https://pubmed.ncbi.nlm.nih.gov/19484493/"",""year"":""2009"",""journal"":""Plant molecular biology"",""authors"":""Xing Y, Jia W, Zhang J."",""matched_aliases"":[""AtMKK1"",""MKK1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
LXL04_002378	gene-LXL04_002378	KAL4589471.1	OH-1004	5	Q5QN75	M2K1_ORYSJ	Swiss-Prot		Mitogen-activated protein kinase kinase 1 OS=Oryza sativa subsp. japonica OX=39947 GN=MKK1 PE=1 SV=1	Oryza sativa subsp. japonica	MKK1	59.76	333	93.503	3.05e-152	435.0	strong_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	Os01g0510100	丝裂原活化蛋白激酶激酶1。	Mitogen-activated protein kinase kinase 1.	[]