query	query_gene_id	query_protein_id	source_reference	hit_rank	swissprot_acc	swissprot_entry	database_section	target_gene_id	description	organism	homolog_gene_name	percent_identity	alignment_length	query_coverage	evalue	bitscore	confidence	evidence_type	source_db	reference_gene_id	reference_function_zh	reference_function_en	reference_papers_json
TkA08G254630	TkA08G254630	TkA08G254630.1	TK1151	1	Q9FJV0	M2K6_ARATH	Swiss-Prot		sp|Q9FJV0|M2K6_ARATH Mitogen-activated protein kinase kinase 6	Arabidopsis thaliana	MKK6	75.3	182	71.542	3.31e-89	271.0	High	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At5g56580	ANPs-MKK6-MPK4 模块参与减数分裂和有丝分裂过程中植物胞质分裂的调节。	The ANPs-MKK6-MPK4 module is involved in the regulation of plant cytokinesis during meiosis and mitosis.	"[{""pmid"":""12704083"",""title"":""NQK1/NtMEK1 is a MAPKK that acts in the NPK1 MAPKKK-mediated MAPK cascade and is required for plant cytokinesis."",""doi"":""10.1101/gad.1071103"",""url"":""https://pubmed.ncbi.nlm.nih.gov/12704083/"",""year"":""2003"",""journal"":""Genes & development"",""authors"":""Soyano T, Nishihama R, Morikiyo K, Ishikawa M, Machida Y."",""matched_aliases"":[""ANQ1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""15474000"",""title"":""The Arabidopsis thaliana MEK AtMKK6 activates the MAP kinase AtMPK13."",""doi"":""10.1016/j.febslet.2004.08.051"",""url"":""https://pubmed.ncbi.nlm.nih.gov/15474000/"",""year"":""2004"",""journal"":""FEBS letters"",""authors"":""Melikant B, Giuliani C, Halbmayer-Watzina S, Limmongkon A, Heberle-Bors E, Wilson C."",""matched_aliases"":[""AtMKK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""20802223"",""title"":""HINKEL kinesin, ANP MAPKKKs and MKK6/ANQ MAPKK, which phosphorylates and activates MPK4 MAPK, constitute a pathway that is required for cytokinesis in Arabidopsis thaliana."",""doi"":""10.1093/pcp/pcq135"",""url"":""https://pubmed.ncbi.nlm.nih.gov/20802223/"",""year"":""2010"",""journal"":""Plant & cell physiology"",""authors"":""Takahashi Y, Soyano T, Kosetsu K, Sasabe M, Machida Y."",""matched_aliases"":[""MKK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""21098735"",""title"":""The MAP kinase MPK4 is required for cytokinesis in Arabidopsis thaliana."",""doi"":""10.1105/tpc.110.077164"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21098735/"",""year"":""2010"",""journal"":""The Plant cell"",""authors"":""Kosetsu K, Matsunaga S, Nakagami H, Colcombet J, Sasabe M, Soyano T, Takahashi Y, Hirt H, Machida Y."",""matched_aliases"":[""MKK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""21575092"",""title"":""AtMPK4 is required for male-specific meiotic cytokinesis in Arabidopsis."",""doi"":""10.1111/j.1365-313x.2011.04642.x"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21575092/"",""year"":""2011"",""journal"":""The Plant journal : for cell and molecular biology"",""authors"":""Zeng Q, Chen JG, Ellis BE."",""matched_aliases"":[""ANQ1"",""AtMKK6"",""MKK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""21904115"",""title"":""AtMKK6 and AtMPK13 are required for lateral root formation in Arabidopsis."",""doi"":""10.4161/psb.6.10.17089"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21904115/"",""year"":""2011"",""journal"":""Plant signaling & behavior"",""authors"":""Zeng Q, Sritubtim S, Ellis BE."",""matched_aliases"":[""AtMKK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
TkA08G254630	TkA08G254630	TkA08G254630.1	TK1151	3	Q9S7U9	M2K2_ARATH	Swiss-Prot		sp|Q9S7U9|M2K2_ARATH Mitogen-activated protein kinase kinase 2	Arabidopsis thaliana	MKK2	57.1	191	75.494	8.03e-70	221.0	High	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At4g29810	MEKK1、MKK1/MKK2 和 MPK4 在信号通路中发挥作用，调节响应生物和非生物胁迫的基因表达，并通过负向调节先天免疫在病原体防御中发挥重要作用。	MEKK1, MKK1/MKK2 and MPK4 function in a signaling pathway that modulates the expression of genes responding to biotic and abiotic stresses and also plays an important role in pathogen defense by negatively regulating innate immunity.	"[{""pmid"":""15225555"",""title"":""The MKK2 pathway mediates cold and salt stress signaling in Arabidopsis."",""doi"":""10.1016/j.molcel.2004.06.023"",""url"":""https://pubmed.ncbi.nlm.nih.gov/15225555/"",""year"":""2004"",""journal"":""Molecular cell"",""authors"":""Teige M, Scheikl E, Eulgem T, Dóczi R, Ichimura K, Shinozaki K, Dangl JL, Hirt H."",""matched_aliases"":[""MKK2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""17506336"",""title"":""The MAP kinase kinase MKK2 affects disease resistance in Arabidopsis."",""doi"":""10.1094/mpmi-20-5-0589"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17506336/"",""year"":""2007"",""journal"":""Molecular plant-microbe interactions : MPMI"",""authors"":""Brader G, Djamei A, Teige M, Palva ET, Hirt H."",""matched_aliases"":[""MKK2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18599650"",""title"":""Arabidopsis mitogen-activated protein kinase kinases MKK1 and MKK2 have overlapping functions in defense signaling mediated by MEKK1, MPK4, and MKS1."",""doi"":""10.1104/pp.108.120006"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18599650/"",""year"":""2008"",""journal"":""Plant physiology"",""authors"":""Qiu JL, Zhou L, Yun BW, Nielsen HB, Fiil BK, Petersen K, Mackinlay J, Loake GJ, Mundy J, Morris PC."",""matched_aliases"":[""MKK2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
TkA08G254630	TkA08G254630	TkA08G254630.1	TK1151	2	Q5QN75	M2K1_ORYSJ	Swiss-Prot		sp|Q5QN75|M2K1_ORYSJ Mitogen-activated protein kinase kinase 1	Oryza sativa subsp. japonica	MKK1	62.7	212	82.213	2.09e-79	246.0	High	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	Os01g0510100	丝裂原活化蛋白激酶激酶1。	Mitogen-activated protein kinase kinase 1.	[]