query	query_gene_id	query_protein_id	source_reference	hit_rank	swissprot_acc	swissprot_entry	database_section	target_gene_id	description	organism	homolog_gene_name	percent_identity	alignment_length	query_coverage	evalue	bitscore	confidence	evidence_type	source_db	reference_gene_id	reference_function_zh	reference_function_en	reference_papers_json
TkA08G169360	TkA08G169360	TkA08G169360.1	TK1151	1	Q9SG02	RDR6_ARATH	Swiss-Prot		sp|Q9SG02|RDR6_ARATH RNA-dependent RNA polymerase 6	Arabidopsis thaliana	RDR6	63.0	1201	100.0	0.0	1565.0	High	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At3g49500	参与转录后基因沉默 的 RNA 依赖性 RNA 聚合酶。	RNA-dependent RNA polymerase involved in post-transcriptional gene silencing (PTGS).	"[{""pmid"":""10850495"",""title"":""Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance."",""doi"":""10.1016/s0092-8674(00)80863-6"",""url"":""https://pubmed.ncbi.nlm.nih.gov/10850495/"",""year"":""2000"",""journal"":""Cell"",""authors"":""Mourrain P, Béclin C, Elmayan T, Feuerbach F, Godon C, Morel JB, Jouette D, Lacombe AM, Nikic S, Picault N, Rémoué K, Sanial M, Vo TA, Vaucheret H."",""matched_aliases"":[""SGS2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""10850496"",""title"":""An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus."",""doi"":""10.1016/s0092-8674(00)80864-8"",""url"":""https://pubmed.ncbi.nlm.nih.gov/10850496/"",""year"":""2000"",""journal"":""Cell"",""authors"":""Dalmay T, Hamilton A, Rudd S, Angell S, Baulcombe DC."",""matched_aliases"":[""SDE1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""15165191"",""title"":""Geminivirus VIGS of endogenous genes requires SGS2/SDE1 and SGS3 and defines a new branch in the genetic pathway for silencing in plants."",""doi"":""10.1111/j.1365-313x.2004.02103.x"",""url"":""https://pubmed.ncbi.nlm.nih.gov/15165191/"",""year"":""2004"",""journal"":""The Plant journal : for cell and molecular biology"",""authors"":""Muangsan N, Beclin C, Vaucheret H, Robertson D."",""matched_aliases"":[""SDE1"",""SGS2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""15466488"",""title"":""SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis."",""doi"":""10.1101/gad.1231804"",""url"":""https://pubmed.ncbi.nlm.nih.gov/15466488/"",""year"":""2004"",""journal"":""Genes & development"",""authors"":""Peragine A, Yoshikawa M, Wu G, Albrecht HL, Poethig RS."",""matched_aliases"":[""RDR6"",""SDE1"",""SGS2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""16006579"",""title"":""The Putative RNA-dependent RNA polymerase RDR6 acts synergistically with ASYMMETRIC LEAVES1 and 2 to repress BREVIPEDICELLUS and MicroRNA165/166 in Arabidopsis leaf development."",""doi"":""10.1105/tpc.105.033449"",""url"":""https://pubmed.ncbi.nlm.nih.gov/16006579/"",""year"":""2005"",""journal"":""The Plant cell"",""authors"":""Li H, Xu L, Wang H, Yuan Z, Cao X, Yang Z, Zhang D, Xu Y, Huang H."",""matched_aliases"":[""RDR6"",""SDE1"",""SGS2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""16131612"",""title"":""A pathway for the biogenesis of trans-acting siRNAs in Arabidopsis."",""doi"":""10.1101/gad.1352605"",""url"":""https://pubmed.ncbi.nlm.nih.gov/16131612/"",""year"":""2005"",""journal"":""Genes & development"",""authors"":""Yoshikawa M, Peragine A, Park MY, Poethig RS."",""matched_aliases"":[""RDR6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""16377568"",""title"":""Endogenous siRNAs derived from a pair of natural cis-antisense transcripts regulate salt tolerance in Arabidopsis."",""doi"":""10.1016/j.cell.2005.11.035"",""url"":""https://pubmed.ncbi.nlm.nih.gov/16377568/"",""year"":""2005"",""journal"":""Cell"",""authors"":""Borsani O, Zhu J, Verslues PE, Sunkar R, Zhu JK."",""matched_aliases"":[""RDR6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""16682354"",""title"":""DRB4-dependent TAS3 trans-acting siRNAs control leaf morphology through AGO7."",""doi"":""10.1016/j.cub.2006.03.035"",""url"":""https://pubmed.ncbi.nlm.nih.gov/16682354/"",""year"":""2006"",""journal"":""Current biology : CB"",""authors"":""Adenot X, Elmayan T, Lauressergues D, Boutet S, Bouché N, Gasciolli V, Vaucheret H."",""matched_aliases"":[""RDR6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""17384170"",""title"":""Improperly terminated, unpolyadenylated mRNA of sense transgenes is targeted by RDR6-mediated RNA silencing in Arabidopsis."",""doi"":""10.1105/tpc.106.045724"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17384170/"",""year"":""2007"",""journal"":""The Plant cell"",""authors"":""Luo Z, Chen Z."",""matched_aliases"":[""RDR6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18063577"",""title"":""Biochemical activities of Arabidopsis RNA-dependent RNA polymerase 6."",""doi"":""10.1074/jbc.m708983200"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18063577/"",""year"":""2008"",""journal"":""The Journal of biological chemistry"",""authors"":""Curaba J, Chen X."",""matched_aliases"":[""RDR6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""19308254"",""title"":""Small RNA deep sequencing reveals role for Arabidopsis thaliana RNA-dependent RNA polymerases in viral siRNA biogenesis."",""doi"":""10.1371/journal.pone.0004971"",""url"":""https://pubmed.ncbi.nlm.nih.gov/19308254/"",""year"":""2009"",""journal"":""PloS one"",""authors"":""Qi X, Bao FS, Xie Z."",""matched_aliases"":[""RDR6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""20562854"",""title"":""Unique functionality of 22-nt miRNAs in triggering RDR6-dependent siRNA biogenesis from target transcripts in Arabidopsis."",""doi"":""10.1038/nsmb.1866"",""url"":""https://pubmed.ncbi.nlm.nih.gov/20562854/"",""year"":""2010"",""journal"":""Nature structural & molecular biology"",""authors"":""Cuperus JT, Carbonell A, Fahlgren N, Garcia-Ruiz H, Burke RT, Takeda A, Sullivan CM, Gilbert SD, Montgomery TA, Carrington JC."",""matched_aliases"":[""RDR6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
TkA08G169360	TkA08G169360	TkA08G169360.1	TK1151	3	Q9LQV2	RDR1_ARATH	Swiss-Prot		sp|Q9LQV2|RDR1_ARATH RNA-dependent RNA polymerase 1	Arabidopsis thaliana	RDR1	37.0	1021	82.805	5.68e-188	583.0	Medium	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At1g14790	RNA依赖性直接聚合酶参与抗病毒沉默。	RNA-dependent direct polymerase involved in antiviral silencing.	"[{""pmid"":""12650452"",""title"":""Analysis of the involvement of an inducible Arabidopsis RNA-dependent RNA polymerase in antiviral defense."",""doi"":""10.1094/mpmi.2003.16.3.206"",""url"":""https://pubmed.ncbi.nlm.nih.gov/12650452/"",""year"":""2003"",""journal"":""Molecular plant-microbe interactions : MPMI"",""authors"":""Yu D, Fan B, MacFarlane SA, Chen Z."",""matched_aliases"":[""AtRDRP1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""19308254"",""title"":""Small RNA deep sequencing reveals role for Arabidopsis thaliana RNA-dependent RNA polymerases in viral siRNA biogenesis."",""doi"":""10.1371/journal.pone.0004971"",""url"":""https://pubmed.ncbi.nlm.nih.gov/19308254/"",""year"":""2009"",""journal"":""PloS one"",""authors"":""Qi X, Bao FS, Xie Z."",""matched_aliases"":[""RDR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""19966292"",""title"":""RNAi-mediated viral immunity requires amplification of virus-derived siRNAs in Arabidopsis thaliana."",""doi"":""10.1073/pnas.0904086107"",""url"":""https://pubmed.ncbi.nlm.nih.gov/19966292/"",""year"":""2010"",""journal"":""Proceedings of the National Academy of Sciences of the United States of America"",""authors"":""Wang XB, Wu Q, Ito T, Cillo F, Li WX, Chen X, Yu JL, Ding SW."",""matched_aliases"":[""RDR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""20190077"",""title"":""Arabidopsis RNA-dependent RNA polymerases and dicer-like proteins in antiviral defense and small interfering RNA biogenesis during Turnip Mosaic Virus infection."",""doi"":""10.1105/tpc.109.073056"",""url"":""https://pubmed.ncbi.nlm.nih.gov/20190077/"",""year"":""2010"",""journal"":""The Plant cell"",""authors"":""Garcia-Ruiz H, Takeda A, Chapman EJ, Sullivan CM, Fahlgren N, Brempelis KJ, Carrington JC."",""matched_aliases"":[""RDR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
TkA08G169360	TkA08G169360	TkA08G169360.1	TK1151	2	Q8LHH9	SHL2_ORYSJ	Swiss-Prot		sp|Q8LHH9|SHL2_ORYSJ Probable RNA-dependent RNA polymerase SHL2	Oryza sativa subsp. japonica	SHL2	57.2	1203	99.332	0.0	1369.0	High	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	Os01g0527600	参与 RNA 沉默途径。	Involved in the RNA silencing pathway.	"[{""pmid"":""17804793"",""title"":""The small interfering RNA production pathway is required for shoot meristem initiation in rice."",""doi"":""10.1073/pnas.0704339104"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17804793/"",""year"":""2007"",""journal"":""Proceedings of the National Academy of Sciences of the United States of America"",""authors"":""Nagasaki H, Itoh J, Hayashi K, Hibara K, Satoh-Nagasawa N, Nosaka M, Mukouhata M, Ashikari M, Kitano H, Matsuoka M, Nagato Y, Sato Y."",""matched_aliases"":[""SHL2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
TkA08G169360	TkA08G169360	TkA08G169360.1	TK1151	4	Q7XM31	RDR2_ORYSJ	Swiss-Prot		sp|Q7XM31|RDR2_ORYSJ Probable RNA-dependent RNA polymerase 2	Oryza sativa subsp. japonica	RDR2	36.4	1007	81.803	5.93e-178	557.0	Medium	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	Os04g0465700	可能参与RNA沉默途径，并且对小干扰RNA（siRNA）的生成是必需的。	Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).	[]
TkA08G169360	TkA08G169360	TkA08G169360.1	TK1151	5	Q0DXS3	RDR1_ORYSJ	Swiss-Prot		sp|Q0DXS3|RDR1_ORYSJ Probable RNA-dependent RNA polymerase 1	Oryza sativa subsp. japonica	RDR1	41.1	767	63.105	9.34e-175	536.0	Medium	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	Os02g0736200	可能参与RNA沉默途径，并且对小干扰RNA（siRNA）的生成是必需的。	Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).	[]