query	query_gene_id	query_protein_id	source_reference	hit_rank	swissprot_acc	swissprot_entry	database_section	target_gene_id	description	organism	homolog_gene_name	percent_identity	alignment_length	query_coverage	evalue	bitscore	confidence	evidence_type	source_db	reference_gene_id	reference_function_zh	reference_function_en	reference_papers_json
TkA08G136830	TkA08G136830	TkA08G136830.1	TK1151	1	Q9STM3	REF6_ARATH	Swiss-Prot		sp|Q9STM3|REF6_ARATH Lysine-specific demethylase REF6	Arabidopsis thaliana	REF6	46.1	674	73.831	8.4e-173	536.0	Medium	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At3g48430	组蛋白去甲基化酶，去甲基化组蛋白 H3 的“赖氨酸-27”（H3K27me），从而作为基因表达的正调控因子。	Histone demethylase that demethylates 'Lys-27' (H3K27me) of histone H3, thus acting as a positive regulator of gene expression.	"[{""pmid"":""15377760"",""title"":""Divergent roles of a pair of homologous jumonji/zinc-finger-class transcription factor proteins in the regulation of Arabidopsis flowering time."",""doi"":""10.1105/tpc.104.025353"",""url"":""https://pubmed.ncbi.nlm.nih.gov/15377760/"",""year"":""2004"",""journal"":""The Plant cell"",""authors"":""Noh B, Lee SH, Kim HJ, Yi G, Shin EA, Lee M, Jung KJ, Doyle MR, Amasino RM, Noh YS."",""matched_aliases"":[""REF6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18467490"",""title"":""Modulation of brassinosteroid-regulated gene expression by Jumonji domain-containing proteins ELF6 and REF6 in Arabidopsis."",""doi"":""10.1073/pnas.0802254105"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18467490/"",""year"":""2008"",""journal"":""Proceedings of the National Academy of Sciences of the United States of America"",""authors"":""Yu X, Li L, Li L, Guo M, Chory J, Yin Y."",""matched_aliases"":[""REF6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""21642989"",""title"":""Arabidopsis REF6 is a histone H3 lysine 27 demethylase."",""doi"":""10.1038/ng.854"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21642989/"",""year"":""2011"",""journal"":""Nature genetics"",""authors"":""Lu F; Cui X; Zhang S; Jenuwein T; Cao X"",""matched_aliases"":[""JMJ12"",""REF6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed""],""fulltext_reviewed"":false},{""pmid"":""25105952"",""title"":""Nuclear factor Y-mediated H3K27me3 demethylation of the SOC1 locus orchestrates flowering responses of Arabidopsis."",""doi"":""10.1038/ncomms5601"",""url"":""https://pubmed.ncbi.nlm.nih.gov/25105952/"",""year"":""2014"",""journal"":""Nature communications"",""authors"":""Hou X; Zhou J; Liu C; Liu L; Shen L; Yu H"",""matched_aliases"":[""REF6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed""],""fulltext_reviewed"":false},{""pmid"":""27111034"",""title"":""Concerted genomic targeting of H3K27 demethylase REF6 and chromatin-remodeling ATPase BRM in Arabidopsis."",""doi"":""10.1038/ng.3555"",""url"":""https://pubmed.ncbi.nlm.nih.gov/27111034/"",""year"":""2016"",""journal"":""Nature genetics"",""authors"":""Li C, Gu L, Gao L, Chen C, Wei CQ, Qiu Q, Chien CW, Wang S, Jiang L, Ai LF, Chen CY, Yang S, Nguyen V, Qi Y, Snyder MP, Burlingame AL, Kohalmi SE, Huang S, Cao X, Wang ZY, Wu K, Chen X, Cui Y."",""matched_aliases"":[""REF6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""27111035"",""title"":""REF6 recognizes a specific DNA sequence to demethylate H3K27me3 and regulate organ boundary formation in Arabidopsis."",""doi"":""10.1038/ng.3556"",""url"":""https://pubmed.ncbi.nlm.nih.gov/27111035/"",""year"":""2016"",""journal"":""Nature genetics"",""authors"":""Cui X; Lu F; Qiu Q; Zhou B; Gu L; Zhang S; Kang Y; Cui X; Ma X; Yao Q; Ma J; Zhang X; Cao X"",""matched_aliases"":[""JMJ12"",""REF6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed""],""fulltext_reviewed"":false},{""pmid"":""30778176"",""title"":""An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis."",""doi"":""10.1038/s41422-019-0145-8"",""url"":""https://pubmed.ncbi.nlm.nih.gov/30778176/"",""year"":""2019"",""journal"":""Cell research"",""authors"":""Liu J, Feng L, Gu X, Deng X, Qiu Q, Li Q, Zhang Y, Wang M, Deng Y, Wang E, He Y, Bäurle I, Li J, Cao X, He Z."",""matched_aliases"":[""REF6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""31048693"",""title"":""DNA methylation repels targeting of Arabidopsis REF6."",""doi"":""10.1038/s41467-019-10026-1"",""url"":""https://pubmed.ncbi.nlm.nih.gov/31048693/"",""year"":""2019"",""journal"":""Nature communications"",""authors"":""Qiu Q; Mei H; Deng X; He K; Wu B; Yao Q; Zhang J; Lu F; Ma J; Cao X"",""matched_aliases"":[""JMJ12"",""REF6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed""],""fulltext_reviewed"":false},{""pmid"":""31418686"",""title"":""Epigenetic silencing of a multifunctional plant stress regulator."",""doi"":""10.7554/elife.47835"",""url"":""https://pubmed.ncbi.nlm.nih.gov/31418686/"",""year"":""2019"",""journal"":""eLife"",""authors"":""Zander M; Willige BC; He Y; Nguyen TA; Langford AE; Nehring R; Howell E; McGrath R; Bartlett A; Castanon R; Nery JR; Chen H; Zhang Z; Jupe F; Stepanova A; Schmitz RJ; Lewsey MG; Chory J; Ecker JR"",""matched_aliases"":[""EIN6"",""REF6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed""],""fulltext_reviewed"":false},{""pmid"":""32257379"",""title"":""Crystal structures of REF6 and its complex with DNA reveal diverse recognition mechanisms."",""doi"":""10.1038/s41421-020-0150-6"",""url"":""https://pubmed.ncbi.nlm.nih.gov/32257379/"",""year"":""2020"",""journal"":""Cell discovery"",""authors"":""Tian Z; Li X; Li M; Wu W; Zhang M; Tang C; Li Z; Liu Y; Chen Z; Yang M; Ma L; Caba C; Tong Y; Lam HM; Dai S; Chen Z"",""matched_aliases"":[""REF6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed""],""fulltext_reviewed"":false},{""pmid"":""32392578"",""title"":""Dehydroabietinal promotes flowering time and plant defense in Arabidopsis via the autonomous pathway genes FLOWERING LOCUS D, FVE, and RELATIVE OF EARLY FLOWERING 6."",""doi"":""10.1093/jxb/eraa232"",""url"":""https://pubmed.ncbi.nlm.nih.gov/32392578/"",""year"":""2020"",""journal"":""Journal of experimental botany"",""authors"":""Chowdhury Z, Mohanty D, Giri MK, Venables BJ, Chaturvedi R, Chao A, Petros RA, Shah J."",""matched_aliases"":[""REF6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""33037128"",""title"":""The H3K27me3 Demethylase RELATIVE OF EARLY FLOWERING6 Suppresses Seed Dormancy by Inducing Abscisic Acid Catabolism."",""doi"":""10.1104/pp.20.01255"",""url"":""https://pubmed.ncbi.nlm.nih.gov/33037128/"",""year"":""2020"",""journal"":""Plant physiology"",""authors"":""Chen H; Tong J; Fu W; Liang Z; Ruan J; Yu Y; Song X; Yuan L; Xiao L; Liu J; Cui Y; Huang S; Li C"",""matched_aliases"":[""REF6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed""],""fulltext_reviewed"":false},{""pmid"":""33107825"",""title"":""A new role for histone demethylases in the maintenance of plant genome integrity."",""doi"":""10.7554/elife.58533"",""url"":""https://pubmed.ncbi.nlm.nih.gov/33107825/"",""year"":""2020"",""journal"":""eLife"",""authors"":""Antunez-Sanchez J, Naish M, Ramirez-Prado JS, Ohno S, Huang Y, Dawson A, Opassathian K, Manza-Mianza D, Ariel F, Raynaud C, Wibowo A, Daron J, Ueda M, Latrasse D, Slotkin RK, Weigel D, Benhamed M, Gutierrez-Marcos J."",""matched_aliases"":[""REF6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
TkA08G136830	TkA08G136830	TkA08G136830.1	TK1151	4	Q6BDA0	ELF6_ARATH	Swiss-Prot		sp|Q6BDA0|ELF6_ARATH Lysine-specific demethylase ELF6	Arabidopsis thaliana	ELF6	43.1	320	37.674	8.6e-69	251.0	Low	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At5g04240	组蛋白去甲基酶，使组蛋白 H3 的“Lys-27” 去甲基化，从而充当基因表达的正调节因子。	Histone demethylase that demethylates 'Lys-27' (H3K27me) of histone H3, thus acting as a positive regulator of gene expression.	"[{""pmid"":""15377760"",""title"":""Divergent roles of a pair of homologous jumonji/zinc-finger-class transcription factor proteins in the regulation of Arabidopsis flowering time."",""doi"":""10.1105/tpc.104.025353"",""url"":""https://pubmed.ncbi.nlm.nih.gov/15377760/"",""year"":""2004"",""journal"":""The Plant cell"",""authors"":""Noh B, Lee SH, Kim HJ, Yi G, Shin EA, Lee M, Jung KJ, Doyle MR, Amasino RM, Noh YS."",""matched_aliases"":[""ELF6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18467490"",""title"":""Modulation of brassinosteroid-regulated gene expression by Jumonji domain-containing proteins ELF6 and REF6 in Arabidopsis."",""doi"":""10.1073/pnas.0802254105"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18467490/"",""year"":""2008"",""journal"":""Proceedings of the National Academy of Sciences of the United States of America"",""authors"":""Yu X, Li L, Li L, Guo M, Chory J, Yin Y."",""matched_aliases"":[""ELF6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""19946624"",""title"":""Repression of FLOWERING LOCUS T chromatin by functionally redundant histone H3 lysine 4 demethylases in Arabidopsis."",""doi"":""10.1371/journal.pone.0008033"",""url"":""https://pubmed.ncbi.nlm.nih.gov/19946624/"",""year"":""2009"",""journal"":""PloS one"",""authors"":""Jeong JH, Song HR, Ko JH, Jeong YM, Kwon YE, Seol JH, Amasino RM, Noh B, Noh YS."",""matched_aliases"":[""ELF6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""25219852"",""title"":""Epigenetic reprogramming that prevents transgenerational inheritance of the vernalized state."",""doi"":""10.1038/nature13722"",""url"":""https://pubmed.ncbi.nlm.nih.gov/25219852/"",""year"":""2014"",""journal"":""Nature"",""authors"":""Crevillén P, Yang H, Cui X, Greeff C, Trick M, Qiu Q, Cao X, Dean C."",""matched_aliases"":[""ELF6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""33107825"",""title"":""A new role for histone demethylases in the maintenance of plant genome integrity."",""doi"":""10.7554/elife.58533"",""url"":""https://pubmed.ncbi.nlm.nih.gov/33107825/"",""year"":""2020"",""journal"":""eLife"",""authors"":""Antunez-Sanchez J, Naish M, Ramirez-Prado JS, Ohno S, Huang Y, Dawson A, Opassathian K, Manza-Mianza D, Ariel F, Raynaud C, Wibowo A, Daron J, Ueda M, Latrasse D, Slotkin RK, Weigel D, Benhamed M, Gutierrez-Marcos J."",""matched_aliases"":[""ELF6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
TkA08G136830	TkA08G136830	TkA08G136830.1	TK1151	5	F4KIX0	JMJ13_ARATH	Swiss-Prot		sp|F4KIX0|JMJ13_ARATH Lysine-specific demethylase JMJ13	Arabidopsis thaliana	JMJ13	51.2	162	19.722	3.62e-37	153.0	Low	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At5g46910	组蛋白去甲基化酶，可将组蛋白 H3 的“Lys-27” 去甲基化，对 H3K27me3 具有特定活性，并参与基因表达的调节。	Histone demethylase that demethylates 'Lys-27' (H3K27me) of histone H3 with a specific activity for H3K27me3 and involved in the regulation of gene expression.	"[{""pmid"":""30899015"",""title"":""The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor."",""doi"":""10.1038/s41467-019-09310-x"",""url"":""https://pubmed.ncbi.nlm.nih.gov/30899015/"",""year"":""2019"",""journal"":""Nature communications"",""authors"":""Zheng S, Hu H, Ren H, Yang Z, Qiu Q, Qi W, Liu X, Chen X, Cui X, Li S, Zhou B, Sun D, Cao X, Du J."",""matched_aliases"":[""JMJ13""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
TkA08G136830	TkA08G136830	TkA08G136830.1	TK1151	2	Q5N712	JM705_ORYSJ	Swiss-Prot		sp|Q5N712|JM705_ORYSJ Lysine-specific demethylase JMJ705	Oryza sativa subsp. japonica	JMJ705	36.4	1051	99.874	3.05e-150	475.0	Medium	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	Os01g0907400	组蛋白去甲基化酶，去甲基化组蛋白H3的'Lys-27'（H3K27me），对H3K27me3和H3K27me2具有特异性活性。	Histone demethylase that demethylates 'Lys-27' (H3K27me) of histone H3 with a specific activity for H3K27me3 and H3K27me2.	"[{""pmid"":""24280387"",""title"":""Jumonji C domain protein JMJ705-mediated removal of histone H3 lysine 27 trimethylation is involved in defense-related gene activation in rice."",""doi"":""10.1105/tpc.113.118802"",""url"":""https://pubmed.ncbi.nlm.nih.gov/24280387/"",""year"":""2013"",""journal"":""The Plant cell"",""authors"":""Li T; Chen X; Zhong X; Zhao Y; Liu X; Zhou S; Cheng S; Zhou DX"",""matched_aliases"":[""JMJ705""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed""],""fulltext_reviewed"":false}]"
TkA08G136830	TkA08G136830	TkA08G136830.1	TK1151	3	Q10RP4	SE14_ORYSJ	Swiss-Prot		sp|Q10RP4|SE14_ORYSJ Probable lysine-specific demethylase SE14	Oryza sativa subsp. japonica	SE14	37.3	571	65.36	4.4e-90	313.0	Medium	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	Os03g0151300	组蛋白去甲基化酶，可使组蛋白 H3 的“Lys-4” 去甲基化。	Histone demethylase that demethylates 'Lys-4' (H3K4me) of histone H3.	"[{""pmid"":""24759811"",""title"":""Se14, encoding a JmjC domain-containing protein, plays key roles in long-day suppression of rice flowering through the demethylation of H3K4me3 of RFT1."",""doi"":""10.1371/journal.pone.0096064"",""url"":""https://pubmed.ncbi.nlm.nih.gov/24759811/"",""year"":""2014"",""journal"":""PloS one"",""authors"":""Yokoo T, Saito H, Yoshitake Y, Xu Q, Asami T, Tsukiyama T, Teraishi M, Okumoto Y, Tanisaka T."",""matched_aliases"":[""Os03g0151300"",""SE14""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"