query	query_gene_id	query_protein_id	source_reference	hit_rank	swissprot_acc	swissprot_entry	database_section	target_gene_id	description	organism	homolog_gene_name	percent_identity	alignment_length	query_coverage	evalue	bitscore	confidence	evidence_type	source_db	reference_gene_id	reference_function_zh	reference_function_en	reference_papers_json
TkA08G054950	TkA08G054950	TkA08G054950.1	TK1151	1	Q39023	MPK3_ARATH	Swiss-Prot		sp|Q39023|MPK3_ARATH Mitogen-activated protein kinase 3	Arabidopsis thaliana	MPK3	82.6	207	100.0	1.46e-125	362.0	High	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At3g45640	参与氧化应激介导的信号级联。	Involved in oxidative stress-mediated signaling cascade (such as ozone).	"[{""pmid"":""11875555"",""title"":""MAP kinase signalling cascade in Arabidopsis innate immunity."",""doi"":""10.1038/415977a"",""url"":""https://pubmed.ncbi.nlm.nih.gov/11875555/"",""year"":""2002"",""journal"":""Nature"",""authors"":""Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J."",""matched_aliases"":[""MPK3""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""15964670"",""title"":""RNA interference-based (RNAi) suppression of AtMPK6, an Arabidopsis mitogen-activated protein kinase, results in hypersensitivity to ozone and misregulation of AtMPK3."",""doi"":""10.1016/j.envpol.2005.04.017"",""url"":""https://pubmed.ncbi.nlm.nih.gov/15964670/"",""year"":""2005"",""journal"":""Environmental pollution (Barking, Essex : 1987)"",""authors"":""Miles GP, Samuel MA, Zhang Y, Ellis BE."",""matched_aliases"":[""AtMPK3"",""MPK3""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""17259259"",""title"":""Stomatal development and patterning are regulated by environmentally responsive mitogen-activated protein kinases in Arabidopsis."",""doi"":""10.1105/tpc.106.048298"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17259259/"",""year"":""2007"",""journal"":""The Plant cell"",""authors"":""Wang H, Ngwenyama N, Liu Y, Walker JC, Zhang S."",""matched_aliases"":[""MPK3""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18273012"",""title"":""Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling."",""doi"":""10.1038/nature06543"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18273012/"",""year"":""2008"",""journal"":""Nature"",""authors"":""Yoo SD, Cho YH, Tena G, Xiong Y, Sheen J."",""matched_aliases"":[""MPK3""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18378893"",""title"":""A fungal-responsive MAPK cascade regulates phytoalexin biosynthesis in Arabidopsis."",""doi"":""10.1073/pnas.0711301105"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18378893/"",""year"":""2008"",""journal"":""Proceedings of the National Academy of Sciences of the United States of America"",""authors"":""Ren D, Liu Y, Yang KY, Han L, Mao G, Glazebrook J, Zhang S."",""matched_aliases"":[""MPK3""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""21276203"",""title"":""The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases."",""doi"":""10.1111/j.1742-4658.2011.08033.x"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21276203/"",""year"":""2011"",""journal"":""The FEBS journal"",""authors"":""Forzani C, Carreri A, de la Fuente van Bentem S, Lecourieux D, Lecourieux F, Hirt H."",""matched_aliases"":[""MPK3""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""21806969"",""title"":""Arabidopsis MKK4 mediates osmotic-stress response via its regulation of MPK3 activity."",""doi"":""10.1016/j.bbrc.2011.07.064"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21806969/"",""year"":""2011"",""journal"":""Biochemical and biophysical research communications"",""authors"":""Kim SH, Woo DH, Kim JM, Lee SY, Chung WS, Moon YH."",""matched_aliases"":[""MPK3""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""23263767"",""title"":""A MAPK cascade downstream of ERECTA receptor-like protein kinase regulates Arabidopsis inflorescence architecture by promoting localized cell proliferation."",""doi"":""10.1105/tpc.112.104695"",""url"":""https://pubmed.ncbi.nlm.nih.gov/23263767/"",""year"":""2012"",""journal"":""The Plant cell"",""authors"":""Meng X, Wang H, He Y, Liu Y, Walker JC, Torii KU, Zhang S."",""matched_aliases"":[""MPK3""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""25010425"",""title"":""Arabidopsis LIP5, a positive regulator of multivesicular body biogenesis, is a critical target of pathogen-responsive MAPK cascade in plant basal defense."",""doi"":""10.1371/journal.ppat.1004243"",""url"":""https://pubmed.ncbi.nlm.nih.gov/25010425/"",""year"":""2014"",""journal"":""PLoS pathogens"",""authors"":""Wang F, Shang Y, Fan B, Yu JQ, Chen Z."",""matched_aliases"":[""MPK3""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""25843888"",""title"":""The BASL polarity protein controls a MAPK signaling feedback loop in asymmetric cell division."",""doi"":""10.1016/j.devcel.2015.02.022"",""url"":""https://pubmed.ncbi.nlm.nih.gov/25843888/"",""year"":""2015"",""journal"":""Developmental cell"",""authors"":""Zhang Y, Wang P, Shao W, Zhu JK, Dong J."",""matched_aliases"":[""MPK3""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
TkA08G054950	TkA08G054950	TkA08G054950.1	TK1151	3	Q39026	MPK6_ARATH	Swiss-Prot		sp|Q39026|MPK6_ARATH Mitogen-activated protein kinase 6	Arabidopsis thaliana	MPK6	79.1	201	97.101	2.45e-115	337.0	High	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At2g43790	丝裂原激活蛋白激酶 ，调节涉及根生长和气孔响应的 MAPKKK20-MKK5-MPK6 级联中的脱落酸 反应。	Mitogen-activated protein kinase (MAPK) which regulates abscisic acid (ABA) responses in a MAPKKK20-MKK5-MPK6 cascade involved in root growth (e.g. root cell division and elongation) and stomatal response.	"[{""pmid"":""11875555"",""title"":""MAP kinase signalling cascade in Arabidopsis innate immunity."",""doi"":""10.1038/415977a"",""url"":""https://pubmed.ncbi.nlm.nih.gov/11875555/"",""year"":""2002"",""journal"":""Nature"",""authors"":""Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J."",""matched_aliases"":[""MPK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""15020743"",""title"":""Silencing of the mitogen-activated protein kinase MPK6 compromises disease resistance in Arabidopsis."",""doi"":""10.1105/tpc.015552"",""url"":""https://pubmed.ncbi.nlm.nih.gov/15020743/"",""year"":""2004"",""journal"":""The Plant cell"",""authors"":""Menke FL, van Pelt JA, Pieterse CM, Klessig DF."",""matched_aliases"":[""MPK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""15225555"",""title"":""The MKK2 pathway mediates cold and salt stress signaling in Arabidopsis."",""doi"":""10.1016/j.molcel.2004.06.023"",""url"":""https://pubmed.ncbi.nlm.nih.gov/15225555/"",""year"":""2004"",""journal"":""Molecular cell"",""authors"":""Teige M, Scheikl E, Eulgem T, Dóczi R, Ichimura K, Shinozaki K, Dangl JL, Hirt H."",""matched_aliases"":[""MPK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""15539472"",""title"":""Phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase by MPK6, a stress-responsive mitogen-activated protein kinase, induces ethylene biosynthesis in Arabidopsis."",""doi"":""10.1105/tpc.104.026609"",""url"":""https://pubmed.ncbi.nlm.nih.gov/15539472/"",""year"":""2004"",""journal"":""The Plant cell"",""authors"":""Liu Y, Zhang S."",""matched_aliases"":[""MPK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""15964670"",""title"":""RNA interference-based (RNAi) suppression of AtMPK6, an Arabidopsis mitogen-activated protein kinase, results in hypersensitivity to ozone and misregulation of AtMPK3."",""doi"":""10.1016/j.envpol.2005.04.017"",""url"":""https://pubmed.ncbi.nlm.nih.gov/15964670/"",""year"":""2005"",""journal"":""Environmental pollution (Barking, Essex : 1987)"",""authors"":""Miles GP, Samuel MA, Zhang Y, Ellis BE."",""matched_aliases"":[""AtMPK6"",""MPK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""17259259"",""title"":""Stomatal development and patterning are regulated by environmentally responsive mitogen-activated protein kinases in Arabidopsis."",""doi"":""10.1105/tpc.106.048298"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17259259/"",""year"":""2007"",""journal"":""The Plant cell"",""authors"":""Wang H, Ngwenyama N, Liu Y, Walker JC, Zhang S."",""matched_aliases"":[""MPK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""17369371"",""title"":""The mitogen-activated protein kinase cascade MKK3-MPK6 is an important part of the jasmonate signal transduction pathway in Arabidopsis."",""doi"":""10.1105/tpc.106.046581"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17369371/"",""year"":""2007"",""journal"":""The Plant cell"",""authors"":""Takahashi F, Yoshida R, Ichimura K, Mizoguchi T, Seo S, Yonezawa M, Maruyama K, Yamaguchi-Shinozaki K, Shinozaki K."",""matched_aliases"":[""MPK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18248592"",""title"":""AtMKK1 mediates ABA-induced CAT1 expression and H2O2 production via AtMPK6-coupled signaling in Arabidopsis."",""doi"":""10.1111/j.1365-313x.2008.03433.x"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18248592/"",""year"":""2008"",""journal"":""The Plant journal : for cell and molecular biology"",""authors"":""Xing Y, Jia W, Zhang J."",""matched_aliases"":[""AtMPK6"",""MPK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18273012"",""title"":""Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling."",""doi"":""10.1038/nature06543"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18273012/"",""year"":""2008"",""journal"":""Nature"",""authors"":""Yoo SD, Cho YH, Tena G, Xiong Y, Sheen J."",""matched_aliases"":[""MPK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18378893"",""title"":""A fungal-responsive MAPK cascade regulates phytoalexin biosynthesis in Arabidopsis."",""doi"":""10.1073/pnas.0711301105"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18378893/"",""year"":""2008"",""journal"":""Proceedings of the National Academy of Sciences of the United States of America"",""authors"":""Ren D, Liu Y, Yang KY, Han L, Mao G, Glazebrook J, Zhang S."",""matched_aliases"":[""MPK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""19251906"",""title"":""An arabidopsis mitogen-activated protein kinase cascade, MKK9-MPK6, plays a role in leaf senescence."",""doi"":""10.1104/pp.108.133439"",""url"":""https://pubmed.ncbi.nlm.nih.gov/19251906/"",""year"":""2009"",""journal"":""Plant physiology"",""authors"":""Zhou C, Cai Z, Guo Y, Gan S."",""matched_aliases"":[""MPK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""19484493"",""title"":""AtMKK1 and AtMPK6 are involved in abscisic acid and sugar signaling in Arabidopsis seed germination."",""doi"":""10.1007/s11103-009-9503-0"",""url"":""https://pubmed.ncbi.nlm.nih.gov/19484493/"",""year"":""2009"",""journal"":""Plant molecular biology"",""authors"":""Xing Y, Jia W, Zhang J."",""matched_aliases"":[""AtMPK6"",""MPK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""21276203"",""title"":""The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases."",""doi"":""10.1111/j.1742-4658.2011.08033.x"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21276203/"",""year"":""2011"",""journal"":""The FEBS journal"",""authors"":""Forzani C, Carreri A, de la Fuente van Bentem S, Lecourieux D, Lecourieux F, Hirt H."",""matched_aliases"":[""MPK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""23263767"",""title"":""A MAPK cascade downstream of ERECTA receptor-like protein kinase regulates Arabidopsis inflorescence architecture by promoting localized cell proliferation."",""doi"":""10.1105/tpc.112.104695"",""url"":""https://pubmed.ncbi.nlm.nih.gov/23263767/"",""year"":""2012"",""journal"":""The Plant cell"",""authors"":""Meng X, Wang H, He Y, Liu Y, Walker JC, Torii KU, Zhang S."",""matched_aliases"":[""MPK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""25010425"",""title"":""Arabidopsis LIP5, a positive regulator of multivesicular body biogenesis, is a critical target of pathogen-responsive MAPK cascade in plant basal defense."",""doi"":""10.1371/journal.ppat.1004243"",""url"":""https://pubmed.ncbi.nlm.nih.gov/25010425/"",""year"":""2014"",""journal"":""PLoS pathogens"",""authors"":""Wang F, Shang Y, Fan B, Yu JQ, Chen Z."",""matched_aliases"":[""MPK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""27913741"",""title"":""AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade."",""doi"":""10.1104/pp.16.01386"",""url"":""https://pubmed.ncbi.nlm.nih.gov/27913741/"",""year"":""2017"",""journal"":""Plant physiology"",""authors"":""Li K, Yang F, Zhang G, Song S, Li Y, Ren D, Miao Y, Song CP."",""matched_aliases"":[""MPK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"