query	query_gene_id	query_protein_id	source_reference	hit_rank	swissprot_acc	swissprot_entry	database_section	target_gene_id	description	organism	homolog_gene_name	percent_identity	alignment_length	query_coverage	evalue	bitscore	confidence	evidence_type	source_db	reference_gene_id	reference_function_zh	reference_function_en	reference_papers_json
TkA05G417520	TkA05G417520	TkA05G417520.1	TK1151	1	Q9SI74	PMI10_ARATH	Swiss-Prot		sp|Q9SI74|PMI10_ARATH Pectinesterase inhibitor 10	Arabidopsis thaliana	PMEI10	40.6	165	79.651	3.03e-28	109.0	Medium	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At1g62760	果胶甲酯酶（PME）抑制剂，参与对坏死性病原体反应中的细胞壁完整性维持。	Pectin methylesterase (PME) inhibitor involved in the maintenance of cell wall integrity in response to necrotrophic pathogens.	[]
TkA05G417520	TkA05G417520	TkA05G417520.1	TK1151	3	Q9SB37	PMEI7_ARATH	Swiss-Prot		sp|Q9SB37|PMEI7_ARATH Pectinesterase inhibitor 7	Arabidopsis thaliana	PMEI7	32.6	193	92.442	6.3e-20	85.5	Medium	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At4g25260	果胶甲酯酶 抑制剂，可以以 pH 依赖性方式靶向 PME3，主要在弱酸性条件下但不在 pH 7.0 下。	Pectin methylesterase (PME) inhibitor that can target PME3 in a pH-dependent manner, mainly in slightly acidic conditions (pH 6.0 and 5.0) but not at pH 7.0.	"[{""pmid"":""26183897"",""title"":""Tuning of Pectin Methylesterification: PECTIN METHYLESTERASE INHIBITOR 7 MODULATES THE PROCESSIVE ACTIVITY OF CO-EXPRESSED PECTIN METHYLESTERASE 3 IN A pH-DEPENDENT MANNER."",""doi"":""10.1074/jbc.m115.639534"",""url"":""https://pubmed.ncbi.nlm.nih.gov/26183897/"",""year"":""2015"",""journal"":""The Journal of biological chemistry"",""authors"":""Sénéchal F, L'Enfant M, Domon JM, Rosiau E, Crépeau MJ, Surcouf O, Esquivel-Rodriguez J, Marcelo P, Mareck A, Guérineau F, Kim HR, Mravec J, Bonnin E, Jamet E, Kihara D, Lerouge P, Ralet MC, Pelloux J, Rayon C."",""matched_aliases"":[""AtPMEI7""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""29109147"",""title"":""Structural and dynamical characterization of the pH-dependence of the pectin methylesterase-pectin methylesterase inhibitor complex."",""doi"":""10.1074/jbc.ra117.000197"",""url"":""https://pubmed.ncbi.nlm.nih.gov/29109147/"",""year"":""2017"",""journal"":""The Journal of biological chemistry"",""authors"":""Sénéchal F, Habrylo O, Hocq L, Domon JM, Marcelo P, Lefebvre V, Pelloux J, Mercadante D."",""matched_aliases"":[""PMEI7""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
TkA05G417520	TkA05G417520	TkA05G417520.1	TK1151	4	Q9SI72	PMEI9_ARATH	Swiss-Prot		sp|Q9SI72|PMEI9_ARATH Pectinesterase inhibitor 9	Arabidopsis thaliana	PMEI9	34.5	171	78.488	4.31e-16	75.5	Medium	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At1g62770	果胶甲酯酶 抑制剂，可能以中等 pH 依赖性方式靶向根部表达的 PME 和 PME3，主要在微酸性条件下，在某种程度上在 pH 7.5 下。	Pectin methylesterase (PME) inhibitor that probably targets root-expressed PME and PME3 in a moderate pH-dependent manner, mainly in slightly acidic conditions (pH 6.3 and 5.0) and to some extent at pH 7.5.	"[{""pmid"":""28034952"",""title"":""Combined Experimental and Computational Approaches Reveal Distinct pH Dependence of Pectin Methylesterase Inhibitors."",""doi"":""10.1104/pp.16.01790"",""url"":""https://pubmed.ncbi.nlm.nih.gov/28034952/"",""year"":""2017"",""journal"":""Plant physiology"",""authors"":""Hocq L, Sénéchal F, Lefebvre V, Lehner A, Domon JM, Mollet JC, Dehors J, Pageau K, Marcelo P, Guérineau F, Kolšek K, Mercadante D, Pelloux J."",""matched_aliases"":[""AtPMEI9""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
TkA05G417520	TkA05G417520	TkA05G417520.1	TK1151	5	Q9SB38	PMEI4_ARATH	Swiss-Prot		sp|Q9SB38|PMEI4_ARATH Pectinesterase inhibitor 4	Arabidopsis thaliana	PMEI4	25.7	167	79.651	1.62e-09	57.8	Low	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At4g25250	果胶甲基酯酶（PME）抑制剂，可靶向根系表达的PME17和PME3，其作用依赖于pH值，主要在略酸性条件下（pH 6.3和5.0）起作用，但在pH 7.5时不发生作用；该过程依赖于参与分子间和分子内相互作用的氨基酸质子化状态的变化。	Pectin methylesterase (PME) inhibitor that can target the root-expressed PME17 and PME3 in a pH-dependent manner, mainly in slightly acidic conditions (pH 6.3 and 5.0) but not at pH 7.5; this processus relies on changes in the protonation of amino acids involved in intermolecular and intramolecular interactions.	"[{""pmid"":""25826258"",""title"":""Arabidopsis PME17 Activity can be Controlled by Pectin Methylesterase Inhibitor4."",""doi"":""10.4161/15592324.2014.983351"",""url"":""https://pubmed.ncbi.nlm.nih.gov/25826258/"",""year"":""2015"",""journal"":""Plant signaling & behavior"",""authors"":""Sénéchal F; Mareck A; Marcelo P; Lerouge P; Pelloux J"",""matched_aliases"":[""PMEI4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed""],""fulltext_reviewed"":false},{""pmid"":""28034952"",""title"":""Combined Experimental and Computational Approaches Reveal Distinct pH Dependence of Pectin Methylesterase Inhibitors."",""doi"":""10.1104/pp.16.01790"",""url"":""https://pubmed.ncbi.nlm.nih.gov/28034952/"",""year"":""2017"",""journal"":""Plant physiology"",""authors"":""Hocq L, Sénéchal F, Lefebvre V, Lehner A, Domon JM, Mollet JC, Dehors J, Pageau K, Marcelo P, Guérineau F, Kolšek K, Mercadante D, Pelloux J."",""matched_aliases"":[""AtPMEI4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"