query	query_gene_id	query_protein_id	source_reference	hit_rank	swissprot_acc	swissprot_entry	database_section	target_gene_id	description	organism	homolog_gene_name	percent_identity	alignment_length	query_coverage	evalue	bitscore	confidence	evidence_type	source_db	reference_gene_id	reference_function_zh	reference_function_en	reference_papers_json
TkA04G388530	TkA04G388530	TkA04G388530.1	TK1151	1	Q93VJ2	IRE1B_ARATH	Swiss-Prot		sp|Q93VJ2|IRE1B_ARATH Serine/threonine-protein kinase/endoribonuclease IRE1b	Arabidopsis thaliana	IRE1B	44.2	502	70.781	2.9e-113	363.0	Medium	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At5g24360	Senses 通过其 N 末端结构域在内质网腔中展开蛋白质，从而导致酶自动激活。	Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation.	"[{""pmid"":""21482766"",""title"":""Heat induces the splicing by IRE1 of a mRNA encoding a transcription factor involved in the unfolded protein response in Arabidopsis."",""doi"":""10.1073/pnas.1102117108"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21482766/"",""year"":""2011"",""journal"":""Proceedings of the National Academy of Sciences of the United States of America"",""authors"":""Deng Y, Humbert S, Liu JX, Srivastava R, Rothstein SJ, Howell SH."",""matched_aliases"":[""IRE1B""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""21914012"",""title"":""AtIRE1A/AtIRE1B and AGB1 independently control two essential unfolded protein response pathways in Arabidopsis."",""doi"":""10.1111/j.1365-313x.2011.04788.x"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21914012/"",""year"":""2012"",""journal"":""The Plant journal : for cell and molecular biology"",""authors"":""Chen Y, Brandizzi F."",""matched_aliases"":[""AtIRE1B""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""22355548"",""title"":""Arabidopsis IRE1 catalyses unconventional splicing of bZIP60 mRNA to produce the active transcription factor."",""doi"":""10.1038/srep00029"",""url"":""https://pubmed.ncbi.nlm.nih.gov/22355548/"",""year"":""2011"",""journal"":""Scientific reports"",""authors"":""Nagashima Y, Mishiba K, Suzuki E, Shimada Y, Iwata Y, Koizumi N."",""matched_aliases"":[""IRE1B""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""22359644"",""title"":""IRE1/bZIP60-mediated unfolded protein response plays distinct roles in plant immunity and abiotic stress responses."",""doi"":""10.1371/journal.pone.0031944"",""url"":""https://pubmed.ncbi.nlm.nih.gov/22359644/"",""year"":""2012"",""journal"":""PloS one"",""authors"":""Moreno AA, Mukhtar MS, Blanco F, Boatwright JL, Moreno I, Jordan MR, Chen Y, Brandizzi F, Dong X, Orellana A, Pajerowska-Mukhtar KM."",""matched_aliases"":[""IRE1B""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""22701744"",""title"":""Alteration of the bZIP60/IRE1 pathway affects plant response to ER stress in Arabidopsis thaliana."",""doi"":""10.1371/journal.pone.0039023"",""url"":""https://pubmed.ncbi.nlm.nih.gov/22701744/"",""year"":""2012"",""journal"":""PloS one"",""authors"":""Humbert S, Zhong S, Deng Y, Howell SH, Rothstein SJ."",""matched_aliases"":[""IRE1B""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""23175745"",""title"":""Degradation of the endoplasmic reticulum by autophagy during endoplasmic reticulum stress in Arabidopsis."",""doi"":""10.1105/tpc.112.101535"",""url"":""https://pubmed.ncbi.nlm.nih.gov/23175745/"",""year"":""2012"",""journal"":""The Plant cell"",""authors"":""Liu Y, Burgos JS, Deng Y, Srivastava R, Howell SH, Bassham DC."",""matched_aliases"":[""IRE1B""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
TkA04G388530	TkA04G388530	TkA04G388530.1	TK1151	2	Q9C5S2	IRE1A_ARATH	Swiss-Prot		sp|Q9C5S2|IRE1A_ARATH Serine/threonine-protein kinase/endoribonuclease IRE1a	Arabidopsis thaliana	IRE1A	47.0	419	59.219	3.87e-110	353.0	Medium	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At2g17520	Senses 通过其 N 末端结构域在内质网腔中展开蛋白质，从而导致酶自动激活。	Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation.	"[{""pmid"":""12020828"",""title"":""Characterization of two homologs of Ire1p, a kinase/endoribonuclease in yeast, in Arabidopsis thaliana."",""doi"":""10.1016/s0167-4781(02)00237-3"",""url"":""https://pubmed.ncbi.nlm.nih.gov/12020828/"",""year"":""2002"",""journal"":""Biochimica et biophysica acta"",""authors"":""Noh SJ, Kwon CS, Chung WI."",""matched_aliases"":[""AtIRE1A""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""21914012"",""title"":""AtIRE1A/AtIRE1B and AGB1 independently control two essential unfolded protein response pathways in Arabidopsis."",""doi"":""10.1111/j.1365-313x.2011.04788.x"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21914012/"",""year"":""2012"",""journal"":""The Plant journal : for cell and molecular biology"",""authors"":""Chen Y, Brandizzi F."",""matched_aliases"":[""AtIRE1A""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""22355548"",""title"":""Arabidopsis IRE1 catalyses unconventional splicing of bZIP60 mRNA to produce the active transcription factor."",""doi"":""10.1038/srep00029"",""url"":""https://pubmed.ncbi.nlm.nih.gov/22355548/"",""year"":""2011"",""journal"":""Scientific reports"",""authors"":""Nagashima Y, Mishiba K, Suzuki E, Shimada Y, Iwata Y, Koizumi N."",""matched_aliases"":[""IRE1A""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""22359644"",""title"":""IRE1/bZIP60-mediated unfolded protein response plays distinct roles in plant immunity and abiotic stress responses."",""doi"":""10.1371/journal.pone.0031944"",""url"":""https://pubmed.ncbi.nlm.nih.gov/22359644/"",""year"":""2012"",""journal"":""PloS one"",""authors"":""Moreno AA, Mukhtar MS, Blanco F, Boatwright JL, Moreno I, Jordan MR, Chen Y, Brandizzi F, Dong X, Orellana A, Pajerowska-Mukhtar KM."",""matched_aliases"":[""IRE1A""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
TkA04G388530	TkA04G388530	TkA04G388530.1	TK1151	3	Q7XIT1	IRE1_ORYSJ	Swiss-Prot		sp|Q7XIT1|IRE1_ORYSJ Serine/threonine-protein kinase/endoribonuclease IRE1	Oryza sativa subsp. japonica	IRE1	47.8	393	59.062	1.18e-102	335.0	Medium	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	Os07g0471000	参与内质网 应激反应。	Involved in endoplasmic reticulum (ER) stress response.	"[{""pmid"":""22050533"",""title"":""Signal transduction by IRE1-mediated splicing of bZIP50 and other stress sensors in the endoplasmic reticulum stress response of rice."",""doi"":""10.1111/j.1365-313x.2011.04844.x"",""url"":""https://pubmed.ncbi.nlm.nih.gov/22050533/"",""year"":""2012"",""journal"":""The Plant journal : for cell and molecular biology"",""authors"":""Hayashi S, Wakasa Y, Takahashi H, Kawakatsu T, Takaiwa F."",""matched_aliases"":[""IRE1"",""OsIRE1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""22199238"",""title"":""Conservation of IRE1-regulated bZIP74 mRNA unconventional splicing in rice (Oryza sativa L.) involved in ER stress responses."",""doi"":""10.1093/mp/ssr115"",""url"":""https://pubmed.ncbi.nlm.nih.gov/22199238/"",""year"":""2012"",""journal"":""Molecular plant"",""authors"":""Lu SJ, Yang ZT, Sun L, Sun L, Song ZT, Liu JX."",""matched_aliases"":[""IRE1"",""OsIRE1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"