query	query_gene_id	query_protein_id	source_reference	hit_rank	swissprot_acc	swissprot_entry	database_section	target_gene_id	description	organism	homolog_gene_name	percent_identity	alignment_length	query_coverage	evalue	bitscore	confidence	evidence_type	source_db	reference_gene_id	reference_function_zh	reference_function_en	reference_papers_json
TkA02G508480	TkA02G508480	TkA02G508480.1	TK1151	1	O80396	M2K3_ARATH	Swiss-Prot		sp|O80396|M2K3_ARATH Mitogen-activated protein kinase kinase 3	Arabidopsis thaliana	MKK3	78.5	516	99.614	3.1e-304	833.0	High	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At5g40440	MKK3-MPK6模块通过负调控MYC2/JIN1表达在茉莉酸信号转导通路中发挥重要作用。	MKK3-MPK6 module plays an important role in the jasmonate signal transduction pathway through the negative regulation of MYC2/JIN1 expression.	"[{""pmid"":""17369371"",""title"":""The mitogen-activated protein kinase cascade MKK3-MPK6 is an important part of the jasmonate signal transduction pathway in Arabidopsis."",""doi"":""10.1105/tpc.106.046581"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17369371/"",""year"":""2007"",""journal"":""The Plant cell"",""authors"":""Takahashi F, Yoshida R, Ichimura K, Mizoguchi T, Seo S, Yonezawa M, Maruyama K, Yamaguchi-Shinozaki K, Shinozaki K."",""matched_aliases"":[""MKK3""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""17933903"",""title"":""The Arabidopsis mitogen-activated protein kinase kinase MKK3 is upstream of group C mitogen-activated protein kinases and participates in pathogen signaling."",""doi"":""10.1105/tpc.106.050039"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17933903/"",""year"":""2007"",""journal"":""The Plant cell"",""authors"":""Dóczi R, Brader G, Pettkó-Szandtner A, Rajh I, Djamei A, Pitzschke A, Teige M, Hirt H."",""matched_aliases"":[""MKK3""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""21419340"",""title"":""Calmodulin-dependent activation of MAP kinase for ROS homeostasis in Arabidopsis."",""doi"":""10.1016/j.molcel.2011.02.029"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21419340/"",""year"":""2011"",""journal"":""Molecular cell"",""authors"":""Takahashi F, Mizoguchi T, Yoshida R, Ichimura K, Shinozaki K."",""matched_aliases"":[""MKK3""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""25720833"",""title"":""Identification and characterization of an ABA-activated MAP kinase cascade in Arabidopsis thaliana."",""doi"":""10.1111/tpj.12808"",""url"":""https://pubmed.ncbi.nlm.nih.gov/25720833/"",""year"":""2015"",""journal"":""The Plant journal : for cell and molecular biology"",""authors"":""Danquah A, de Zélicourt A, Boudsocq M, Neubauer J, Frei Dit Frey N, Leonhardt N, Pateyron S, Gwinner F, Tamby JP, Ortiz-Masia D, Marcote MJ, Hirt H, Colcombet J."",""matched_aliases"":[""MKK3""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""28848569"",""title"":""The  Arabidopsis  Mitogen-Activated Protein Kinase Kinase Kinase 20 (MKKK20) Acts Upstream of MKK3 and MPK18 in Two Separate Signaling Pathways Involved in Root Microtubule Functions."",""doi"":""10.3389/fpls.2017.01352"",""url"":""https://pubmed.ncbi.nlm.nih.gov/28848569/"",""year"":""2017"",""journal"":""Frontiers in plant science"",""authors"":""Benhamman R, Bai F, Drory SB, Loubert-Hudon A, Ellis B, Matton DP."",""matched_aliases"":[""MKK3""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
TkA02G508480	TkA02G508480	TkA02G508480.1	TK1151	2	Q9FJV0	M2K6_ARATH	Swiss-Prot		sp|Q9FJV0|M2K6_ARATH Mitogen-activated protein kinase kinase 6	Arabidopsis thaliana	MKK6	42.0	324	61.004	1.89e-78	253.0	Medium	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	At5g56580	ANPs-MKK6-MPK4 模块参与减数分裂和有丝分裂过程中植物胞质分裂的调节。	The ANPs-MKK6-MPK4 module is involved in the regulation of plant cytokinesis during meiosis and mitosis.	"[{""pmid"":""12704083"",""title"":""NQK1/NtMEK1 is a MAPKK that acts in the NPK1 MAPKKK-mediated MAPK cascade and is required for plant cytokinesis."",""doi"":""10.1101/gad.1071103"",""url"":""https://pubmed.ncbi.nlm.nih.gov/12704083/"",""year"":""2003"",""journal"":""Genes & development"",""authors"":""Soyano T, Nishihama R, Morikiyo K, Ishikawa M, Machida Y."",""matched_aliases"":[""ANQ1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""15474000"",""title"":""The Arabidopsis thaliana MEK AtMKK6 activates the MAP kinase AtMPK13."",""doi"":""10.1016/j.febslet.2004.08.051"",""url"":""https://pubmed.ncbi.nlm.nih.gov/15474000/"",""year"":""2004"",""journal"":""FEBS letters"",""authors"":""Melikant B, Giuliani C, Halbmayer-Watzina S, Limmongkon A, Heberle-Bors E, Wilson C."",""matched_aliases"":[""AtMKK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""20802223"",""title"":""HINKEL kinesin, ANP MAPKKKs and MKK6/ANQ MAPKK, which phosphorylates and activates MPK4 MAPK, constitute a pathway that is required for cytokinesis in Arabidopsis thaliana."",""doi"":""10.1093/pcp/pcq135"",""url"":""https://pubmed.ncbi.nlm.nih.gov/20802223/"",""year"":""2010"",""journal"":""Plant & cell physiology"",""authors"":""Takahashi Y, Soyano T, Kosetsu K, Sasabe M, Machida Y."",""matched_aliases"":[""MKK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""21098735"",""title"":""The MAP kinase MPK4 is required for cytokinesis in Arabidopsis thaliana."",""doi"":""10.1105/tpc.110.077164"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21098735/"",""year"":""2010"",""journal"":""The Plant cell"",""authors"":""Kosetsu K, Matsunaga S, Nakagami H, Colcombet J, Sasabe M, Soyano T, Takahashi Y, Hirt H, Machida Y."",""matched_aliases"":[""MKK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""21575092"",""title"":""AtMPK4 is required for male-specific meiotic cytokinesis in Arabidopsis."",""doi"":""10.1111/j.1365-313x.2011.04642.x"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21575092/"",""year"":""2011"",""journal"":""The Plant journal : for cell and molecular biology"",""authors"":""Zeng Q, Chen JG, Ellis BE."",""matched_aliases"":[""ANQ1"",""AtMKK6"",""MKK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""21904115"",""title"":""AtMKK6 and AtMPK13 are required for lateral root formation in Arabidopsis."",""doi"":""10.4161/psb.6.10.17089"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21904115/"",""year"":""2011"",""journal"":""Plant signaling & behavior"",""authors"":""Zeng Q, Sritubtim S, Ellis BE."",""matched_aliases"":[""AtMKK6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
TkA02G508480	TkA02G508480	TkA02G508480.1	TK1151	5	Q5QN75	M2K1_ORYSJ	Swiss-Prot		sp|Q5QN75|M2K1_ORYSJ Mitogen-activated protein kinase kinase 1	Oryza sativa subsp. japonica	MKK1	41.9	320	60.039	9.46e-75	243.0	Medium	TK1151 direct protein BLASTP	UniProt Swiss-Prot local database (DIAMOND)	Os01g0510100	丝裂原活化蛋白激酶激酶1。	Mitogen-activated protein kinase kinase 1.	[]