query	query_gene_id	query_protein_id	source_reference	hit_rank	swissprot_acc	swissprot_entry	database_section	target_gene_id	description	organism	homolog_gene_name	percent_identity	alignment_length	query_coverage	evalue	bitscore	confidence	evidence_type	source_db	reference_gene_id	reference_function_zh	reference_function_en	reference_papers_json
LXL04_033209	gene-LXL04_033209	KAL4561047.1	OH-1004	2	Q9ZVD5	AGO4_ARATH	Swiss-Prot		Protein argonaute 4 OS=Arabidopsis thaliana OX=3702 GN=AGO4 PE=1 SV=2	Arabidopsis thaliana	AGO4	75.0	32	25.0	8.09e-07	50.1	weak_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	At2g27040	与 RDM3 一起，是通过 DNA 甲基化和几个染色质位点的抑制性组蛋白修饰 实现转录基因沉默 所必需的。	Together with RDM3, required for transcriptional gene silencing (TGS) by DNA methylation and repressive histone modifications (H3K9me2) of several chromatin loci.	"[{""pmid"":""12522258"",""title"":""ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation."",""doi"":""10.1126/science.1079695"",""url"":""https://pubmed.ncbi.nlm.nih.gov/12522258/"",""year"":""2003"",""journal"":""Science (New York, N.Y.)"",""authors"":""Zilberman D, Cao X, Jacobsen SE."",""matched_aliases"":[""AGO4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""15242620"",""title"":""Role of Arabidopsis ARGONAUTE4 in RNA-directed DNA methylation triggered by inverted repeats."",""doi"":""10.1016/j.cub.2004.06.055"",""url"":""https://pubmed.ncbi.nlm.nih.gov/15242620/"",""year"":""2004"",""journal"":""Current biology : CB"",""authors"":""Zilberman D, Cao X, Johansen LK, Xie Z, Carrington JC, Jacobsen SE."",""matched_aliases"":[""AGO4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""16839878"",""title"":""The Arabidopsis chromatin-modifying nuclear siRNA pathway involves a nucleolar RNA processing center."",""doi"":""10.1016/j.cell.2006.05.031"",""url"":""https://pubmed.ncbi.nlm.nih.gov/16839878/"",""year"":""2006"",""journal"":""Cell"",""authors"":""Pontes O, Li CF, Costa Nunes P, Haag J, Ream T, Vitins A, Jacobsen SE, Pikaard CS."",""matched_aliases"":[""AGO4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""16839879"",""title"":""An ARGONAUTE4-containing nuclear processing center colocalized with Cajal bodies in Arabidopsis thaliana."",""doi"":""10.1016/j.cell.2006.05.032"",""url"":""https://pubmed.ncbi.nlm.nih.gov/16839879/"",""year"":""2006"",""journal"":""Cell"",""authors"":""Li CF, Pontes O, El-Shami M, Henderson IR, Henderson IR, Bernatavichute YV, Chan SW, Lagrange T, Pikaard CS, Jacobsen SE."",""matched_aliases"":[""AGO4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""16998468"",""title"":""Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation."",""doi"":""10.1038/nature05198"",""url"":""https://pubmed.ncbi.nlm.nih.gov/16998468/"",""year"":""2006"",""journal"":""Nature"",""authors"":""Qi Y, He X, Wang XJ, Kohany O, Jurka J, Hannon GJ."",""matched_aliases"":[""AGO4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""17938239"",""title"":""Reiterated WG/GW motifs form functionally and evolutionarily conserved ARGONAUTE-binding platforms in RNAi-related components."",""doi"":""10.1101/gad.451207"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17938239/"",""year"":""2007"",""journal"":""Genes & development"",""authors"":""El-Shami M, Pontier D, Lahmy S, Braun L, Picart C, Vega D, Hakimi MA, Jacobsen SE, Cooke R, Lagrange T."",""matched_aliases"":[""AGO4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""17993621"",""title"":""ARGONAUTE4 is required for resistance to Pseudomonas syringae in Arabidopsis."",""doi"":""10.1105/tpc.107.054494"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17993621/"",""year"":""2007"",""journal"":""The Plant cell"",""authors"":""Agorio A, Vera P."",""matched_aliases"":[""AGO4"",""OCP11""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18342361"",""title"":""Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide."",""doi"":""10.1016/j.cell.2008.02.034"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18342361/"",""year"":""2008"",""journal"":""Cell"",""authors"":""Mi S, Cai T, Hu Y, Chen Y, Hodges E, Ni F, Wu L, Li S, Zhou H, Long C, Chen S, Hannon GJ, Qi Y."",""matched_aliases"":[""AGO4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18596098"",""title"":""Viral genome methylation as an epigenetic defense against geminiviruses."",""doi"":""10.1128/jvi.00719-08"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18596098/"",""year"":""2008"",""journal"":""Journal of virology"",""authors"":""Raja P, Sanville BC, Buchmann RC, Bisaro DM."",""matched_aliases"":[""AGO4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""19377477"",""title"":""RNA polymerase V transcription guides ARGONAUTE4 to chromatin."",""doi"":""10.1038/ng.365"",""url"":""https://pubmed.ncbi.nlm.nih.gov/19377477/"",""year"":""2009"",""journal"":""Nature genetics"",""authors"":""Wierzbicki AT, Ream TS, Haag JR, Pikaard CS."",""matched_aliases"":[""AGO4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""20173091"",""title"":""The Arabidopsis RNA-directed DNA methylation argonautes functionally diverge based on their expression and interaction with target loci."",""doi"":""10.1105/tpc.109.072199"",""url"":""https://pubmed.ncbi.nlm.nih.gov/20173091/"",""year"":""2010"",""journal"":""The Plant cell"",""authors"":""Havecker ER, Wallbridge LM, Hardcastle TJ, Bush MS, Kelly KA, Dunn RM, Schwach F, Doonan JH, Baulcombe DC."",""matched_aliases"":[""AGO4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""21738482"",""title"":""Independent chromatin binding of ARGONAUTE4 and SPT5L/KTF1 mediates transcriptional gene silencing."",""doi"":""10.1371/journal.pgen.1002120"",""url"":""https://pubmed.ncbi.nlm.nih.gov/21738482/"",""year"":""2011"",""journal"":""PLoS genetics"",""authors"":""Rowley MJ, Avrutsky MI, Sifuentes CJ, Pereira L, Wierzbicki AT."",""matched_aliases"":[""AGO4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
LXL04_033209	gene-LXL04_033209	KAL4561047.1	OH-1004	1	Q9SDG8	AGO4A_ORYSJ	Swiss-Prot		Protein argonaute 4A OS=Oryza sativa subsp. japonica OX=39947 GN=AGO4A PE=2 SV=1	Oryza sativa subsp. japonica	AGO4A	62.5	40	31.25	4.44e-07	50.8	weak_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	Os01g0275600	可能参与RNA沉默途径。	Probably involved in the RNA silencing pathway.	[]
LXL04_033209	gene-LXL04_033209	KAL4561047.1	OH-1004	3	Q0JF58	AGO4B_ORYSJ	Swiss-Prot		Protein argonaute 4B OS=Oryza sativa subsp. japonica OX=39947 GN=AGO4B PE=2 SV=1	Oryza sativa subsp. japonica	AGO4B	71.875	32	25.0	1.08e-06	49.7	weak_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	Os04g0151800	可能参与RNA沉默途径。	Probably involved in the RNA silencing pathway.	[]