query	query_gene_id	query_protein_id	source_reference	hit_rank	swissprot_acc	swissprot_entry	database_section	target_gene_id	description	organism	homolog_gene_name	percent_identity	alignment_length	query_coverage	evalue	bitscore	confidence	evidence_type	source_db	reference_gene_id	reference_function_zh	reference_function_en	reference_papers_json
LXL04_027523	gene-LXL04_027523	KAL4563480.1	OH-1004	1	Q8LGH4	CUL4_ARATH	Swiss-Prot		Cullin-4 OS=Arabidopsis thaliana OX=3702 GN=CUL4 PE=1 SV=1	Arabidopsis thaliana	CUL4	83.267	753	90.614	0.0	1265.0	strong_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	At5g46210	CUL4-RBX1-CDD（COP10-DDB1a-DET1）型E3泛素蛋白连接酶复合物的组分，介导靶蛋白的泛素化及随后的蛋白酶体降解。	Component of the CUL4-RBX1-CDD (COP10-DDB1a-DET1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.	"[{""pmid"":""16792691"",""title"":""CUL4 associates with DDB1 and DET1 and its downregulation affects diverse aspects of development in Arabidopsis thaliana."",""doi"":""10.1111/j.1365-313x.2006.02810.x"",""url"":""https://pubmed.ncbi.nlm.nih.gov/16792691/"",""year"":""2006"",""journal"":""The Plant journal : for cell and molecular biology"",""authors"":""Bernhardt A, Lechner E, Hano P, Schade V, Dieterle M, Anders M, Dubin MJ, Benvenuto G, Bowler C, Genschik P, Hellmann H."",""matched_aliases"":[""CUL4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""16844902"",""title"":""Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development."",""doi"":""10.1105/tpc.106.043224"",""url"":""https://pubmed.ncbi.nlm.nih.gov/16844902/"",""year"":""2006"",""journal"":""The Plant cell"",""authors"":""Chen H, Shen Y, Tang X, Yu L, Wang J, Guo L, Zhang Y, Zhang H, Feng S, Strickland E, Zheng N, Deng XW."",""matched_aliases"":[""CUL4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18223036"",""title"":""Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases."",""doi"":""10.1105/tpc.107.055418"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18223036/"",""year"":""2008"",""journal"":""The Plant cell"",""authors"":""Lee JH, Terzaghi W, Gusmaroli G, Charron JB, Yoon HJ, Chen H, He YJ, Xiong Y, Deng XW."",""matched_aliases"":[""CUL4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18552200"",""title"":""Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes."",""doi"":""10.1105/tpc.108.058891"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18552200/"",""year"":""2008"",""journal"":""The Plant cell"",""authors"":""Zhang Y, Feng S, Chen F, Chen H, Wang J, McCall C, Xiong Y, Deng XW."",""matched_aliases"":[""CUL4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""20061554"",""title"":""Arabidopsis CULLIN4-damaged DNA binding protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time."",""doi"":""10.1105/tpc.109.065490"",""url"":""https://pubmed.ncbi.nlm.nih.gov/20061554/"",""year"":""2010"",""journal"":""The Plant cell"",""authors"":""Chen H, Huang X, Gusmaroli G, Terzaghi W, Lau OS, Yanagawa Y, Zhang Y, Li J, Lee JH, Zhu D, Deng XW."",""matched_aliases"":[""CUL4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""20525848"",""title"":""DWA1 and DWA2, two Arabidopsis DWD protein components of CUL4-based E3 ligases, act together as negative regulators in ABA signal transduction."",""doi"":""10.1105/tpc.109.073783"",""url"":""https://pubmed.ncbi.nlm.nih.gov/20525848/"",""year"":""2010"",""journal"":""The Plant cell"",""authors"":""Lee JH, Yoon HJ, Terzaghi W, Martinez C, Dai M, Li J, Byun MO, Deng XW."",""matched_aliases"":[""CUL4""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"