query	query_gene_id	query_protein_id	source_reference	hit_rank	swissprot_acc	swissprot_entry	database_section	target_gene_id	description	organism	homolog_gene_name	percent_identity	alignment_length	query_coverage	evalue	bitscore	confidence	evidence_type	source_db	reference_gene_id	reference_function_zh	reference_function_en	reference_papers_json
LXL04_022502	gene-LXL04_022502	KAL4575651.1	OH-1004	1	Q9LQV2	RDR1_ARATH	Swiss-Prot		RNA-dependent RNA polymerase 1 OS=Arabidopsis thaliana OX=3702 GN=RDR1 PE=2 SV=1	Arabidopsis thaliana	RDR1	61.096	1113	99.186	0.0	1365.0	strong_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	At1g14790	RNA依赖性直接聚合酶参与抗病毒沉默。	RNA-dependent direct polymerase involved in antiviral silencing.	"[{""pmid"":""12650452"",""title"":""Analysis of the involvement of an inducible Arabidopsis RNA-dependent RNA polymerase in antiviral defense."",""doi"":""10.1094/mpmi.2003.16.3.206"",""url"":""https://pubmed.ncbi.nlm.nih.gov/12650452/"",""year"":""2003"",""journal"":""Molecular plant-microbe interactions : MPMI"",""authors"":""Yu D, Fan B, MacFarlane SA, Chen Z."",""matched_aliases"":[""AtRDRP1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""19308254"",""title"":""Small RNA deep sequencing reveals role for Arabidopsis thaliana RNA-dependent RNA polymerases in viral siRNA biogenesis."",""doi"":""10.1371/journal.pone.0004971"",""url"":""https://pubmed.ncbi.nlm.nih.gov/19308254/"",""year"":""2009"",""journal"":""PloS one"",""authors"":""Qi X, Bao FS, Xie Z."",""matched_aliases"":[""RDR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""19966292"",""title"":""RNAi-mediated viral immunity requires amplification of virus-derived siRNAs in Arabidopsis thaliana."",""doi"":""10.1073/pnas.0904086107"",""url"":""https://pubmed.ncbi.nlm.nih.gov/19966292/"",""year"":""2010"",""journal"":""Proceedings of the National Academy of Sciences of the United States of America"",""authors"":""Wang XB, Wu Q, Ito T, Cillo F, Li WX, Chen X, Yu JL, Ding SW."",""matched_aliases"":[""RDR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""20190077"",""title"":""Arabidopsis RNA-dependent RNA polymerases and dicer-like proteins in antiviral defense and small interfering RNA biogenesis during Turnip Mosaic Virus infection."",""doi"":""10.1105/tpc.109.073056"",""url"":""https://pubmed.ncbi.nlm.nih.gov/20190077/"",""year"":""2010"",""journal"":""The Plant cell"",""authors"":""Garcia-Ruiz H, Takeda A, Chapman EJ, Sullivan CM, Fahlgren N, Brempelis KJ, Carrington JC."",""matched_aliases"":[""RDR1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
LXL04_022502	gene-LXL04_022502	KAL4575651.1	OH-1004	3	O82504	RDR2_ARATH	Swiss-Prot		RNA-dependent RNA polymerase 2 OS=Arabidopsis thaliana OX=3702 GN=RDR2 PE=1 SV=1	Arabidopsis thaliana	RDR2	39.235	1124	97.376	0.0	768.0	moderate_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	At4g11130	RNA 依赖性直接聚合酶参与小干扰 RNA 的产生。	RNA-dependent direct polymerase involved in the production of small interfering RNAs (siRNAs).	"[{""pmid"":""15024409"",""title"":""Genetic and functional diversification of small RNA pathways in plants."",""doi"":""10.1371/journal.pbio.0020104"",""url"":""https://pubmed.ncbi.nlm.nih.gov/15024409/"",""year"":""2004"",""journal"":""PLoS biology"",""authors"":""Xie Z, Johansen LK, Gustafson AM, Kasschau KD, Lellis AD, Zilberman D, Jacobsen SE, Carrington JC."",""matched_aliases"":[""RDR2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""16798886"",""title"":""MicroRNA-targeted and small interfering RNA-mediated mRNA degradation is regulated by argonaute, dicer, and RNA-dependent RNA polymerase in Arabidopsis."",""doi"":""10.1105/tpc.106.042127"",""url"":""https://pubmed.ncbi.nlm.nih.gov/16798886/"",""year"":""2006"",""journal"":""The Plant cell"",""authors"":""Ronemus M, Vaughn MW, Martienssen RA."",""matched_aliases"":[""RDR2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""17526749"",""title"":""An SNF2 protein associated with nuclear RNA silencing and the spread of a silencing signal between cells in Arabidopsis."",""doi"":""10.1105/tpc.107.051540"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17526749/"",""year"":""2007"",""journal"":""The Plant cell"",""authors"":""Smith LM, Pontes O, Searle I, Yelina N, Yousafzai FK, Herr AJ, Pikaard CS, Baulcombe DC."",""matched_aliases"":[""RDR2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""17785412"",""title"":""Nuclear gene silencing directs reception of long-distance mRNA silencing in Arabidopsis."",""doi"":""10.1073/pnas.0706701104"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17785412/"",""year"":""2007"",""journal"":""Proceedings of the National Academy of Sciences of the United States of America"",""authors"":""Brosnan CA, Mitter N, Christie M, Smith NA, Waterhouse PM, Carroll BJ."",""matched_aliases"":[""RDR2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""20548962"",""title"":""siRNA-mediated methylation of Arabidopsis telomeres."",""doi"":""10.1371/journal.pgen.1000986"",""url"":""https://pubmed.ncbi.nlm.nih.gov/20548962/"",""year"":""2010"",""journal"":""PLoS genetics"",""authors"":""Vrbsky J, Akimcheva S, Watson JM, Turner TL, Daxinger L, Vyskot B, Aufsatz W, Riha K."",""matched_aliases"":[""RDR2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""23142082"",""title"":""In vitro transcription activities of Pol IV, Pol V, and RDR2 reveal coupling of Pol IV and RDR2 for dsRNA synthesis in plant RNA silencing."",""doi"":""10.1016/j.molcel.2012.09.027"",""url"":""https://pubmed.ncbi.nlm.nih.gov/23142082/"",""year"":""2012"",""journal"":""Molecular cell"",""authors"":""Haag JR, Ream TS, Marasco M, Nicora CD, Norbeck AD, Pasa-Tolic L, Pikaard CS."",""matched_aliases"":[""RDR2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""34903670"",""title"":""Structure and RNA template requirements of  Arabidopsis  RNA-DEPENDENT RNA POLYMERASE 2."",""doi"":""10.1073/pnas.2115899118"",""url"":""https://pubmed.ncbi.nlm.nih.gov/34903670/"",""year"":""2021"",""journal"":""Proceedings of the National Academy of Sciences of the United States of America"",""authors"":""Fukudome A, Singh J, Mishra V, Reddem E, Martinez-Marquez F, Wenzel S, Yan R, Shiozaki M, Yu Z, Wang JC, Takagi Y, Pikaard CS."",""matched_aliases"":[""RDR2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
LXL04_022502	gene-LXL04_022502	KAL4575651.1	OH-1004	5	Q9SG02	RDR6_ARATH	Swiss-Prot		RNA-dependent RNA polymerase 6 OS=Arabidopsis thaliana OX=3702 GN=RDR6 PE=1 SV=1	Arabidopsis thaliana	RDR6	35.671	1155	97.014	0.0	578.0	moderate_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	At3g49500	参与转录后基因沉默 的 RNA 依赖性 RNA 聚合酶。	RNA-dependent RNA polymerase involved in post-transcriptional gene silencing (PTGS).	"[{""pmid"":""10850495"",""title"":""Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance."",""doi"":""10.1016/s0092-8674(00)80863-6"",""url"":""https://pubmed.ncbi.nlm.nih.gov/10850495/"",""year"":""2000"",""journal"":""Cell"",""authors"":""Mourrain P, Béclin C, Elmayan T, Feuerbach F, Godon C, Morel JB, Jouette D, Lacombe AM, Nikic S, Picault N, Rémoué K, Sanial M, Vo TA, Vaucheret H."",""matched_aliases"":[""SGS2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""10850496"",""title"":""An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus."",""doi"":""10.1016/s0092-8674(00)80864-8"",""url"":""https://pubmed.ncbi.nlm.nih.gov/10850496/"",""year"":""2000"",""journal"":""Cell"",""authors"":""Dalmay T, Hamilton A, Rudd S, Angell S, Baulcombe DC."",""matched_aliases"":[""SDE1""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""15165191"",""title"":""Geminivirus VIGS of endogenous genes requires SGS2/SDE1 and SGS3 and defines a new branch in the genetic pathway for silencing in plants."",""doi"":""10.1111/j.1365-313x.2004.02103.x"",""url"":""https://pubmed.ncbi.nlm.nih.gov/15165191/"",""year"":""2004"",""journal"":""The Plant journal : for cell and molecular biology"",""authors"":""Muangsan N, Beclin C, Vaucheret H, Robertson D."",""matched_aliases"":[""SDE1"",""SGS2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""15466488"",""title"":""SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis."",""doi"":""10.1101/gad.1231804"",""url"":""https://pubmed.ncbi.nlm.nih.gov/15466488/"",""year"":""2004"",""journal"":""Genes & development"",""authors"":""Peragine A, Yoshikawa M, Wu G, Albrecht HL, Poethig RS."",""matched_aliases"":[""RDR6"",""SDE1"",""SGS2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""16006579"",""title"":""The Putative RNA-dependent RNA polymerase RDR6 acts synergistically with ASYMMETRIC LEAVES1 and 2 to repress BREVIPEDICELLUS and MicroRNA165/166 in Arabidopsis leaf development."",""doi"":""10.1105/tpc.105.033449"",""url"":""https://pubmed.ncbi.nlm.nih.gov/16006579/"",""year"":""2005"",""journal"":""The Plant cell"",""authors"":""Li H, Xu L, Wang H, Yuan Z, Cao X, Yang Z, Zhang D, Xu Y, Huang H."",""matched_aliases"":[""RDR6"",""SDE1"",""SGS2""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""16131612"",""title"":""A pathway for the biogenesis of trans-acting siRNAs in Arabidopsis."",""doi"":""10.1101/gad.1352605"",""url"":""https://pubmed.ncbi.nlm.nih.gov/16131612/"",""year"":""2005"",""journal"":""Genes & development"",""authors"":""Yoshikawa M, Peragine A, Park MY, Poethig RS."",""matched_aliases"":[""RDR6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""16377568"",""title"":""Endogenous siRNAs derived from a pair of natural cis-antisense transcripts regulate salt tolerance in Arabidopsis."",""doi"":""10.1016/j.cell.2005.11.035"",""url"":""https://pubmed.ncbi.nlm.nih.gov/16377568/"",""year"":""2005"",""journal"":""Cell"",""authors"":""Borsani O, Zhu J, Verslues PE, Sunkar R, Zhu JK."",""matched_aliases"":[""RDR6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""16682354"",""title"":""DRB4-dependent TAS3 trans-acting siRNAs control leaf morphology through AGO7."",""doi"":""10.1016/j.cub.2006.03.035"",""url"":""https://pubmed.ncbi.nlm.nih.gov/16682354/"",""year"":""2006"",""journal"":""Current biology : CB"",""authors"":""Adenot X, Elmayan T, Lauressergues D, Boutet S, Bouché N, Gasciolli V, Vaucheret H."",""matched_aliases"":[""RDR6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""17384170"",""title"":""Improperly terminated, unpolyadenylated mRNA of sense transgenes is targeted by RDR6-mediated RNA silencing in Arabidopsis."",""doi"":""10.1105/tpc.106.045724"",""url"":""https://pubmed.ncbi.nlm.nih.gov/17384170/"",""year"":""2007"",""journal"":""The Plant cell"",""authors"":""Luo Z, Chen Z."",""matched_aliases"":[""RDR6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""18063577"",""title"":""Biochemical activities of Arabidopsis RNA-dependent RNA polymerase 6."",""doi"":""10.1074/jbc.m708983200"",""url"":""https://pubmed.ncbi.nlm.nih.gov/18063577/"",""year"":""2008"",""journal"":""The Journal of biological chemistry"",""authors"":""Curaba J, Chen X."",""matched_aliases"":[""RDR6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""19308254"",""title"":""Small RNA deep sequencing reveals role for Arabidopsis thaliana RNA-dependent RNA polymerases in viral siRNA biogenesis."",""doi"":""10.1371/journal.pone.0004971"",""url"":""https://pubmed.ncbi.nlm.nih.gov/19308254/"",""year"":""2009"",""journal"":""PloS one"",""authors"":""Qi X, Bao FS, Xie Z."",""matched_aliases"":[""RDR6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false},{""pmid"":""20562854"",""title"":""Unique functionality of 22-nt miRNAs in triggering RDR6-dependent siRNA biogenesis from target transcripts in Arabidopsis."",""doi"":""10.1038/nsmb.1866"",""url"":""https://pubmed.ncbi.nlm.nih.gov/20562854/"",""year"":""2010"",""journal"":""Nature structural & molecular biology"",""authors"":""Cuperus JT, Carbonell A, Fahlgren N, Garcia-Ruiz H, Burke RT, Takeda A, Sullivan CM, Gilbert SD, Montgomery TA, Carrington JC."",""matched_aliases"":[""RDR6""],""evidence"":""UniProt FUNCTION; UniProt/PubMed metadata and gene/species abstract checks; EuropePMC cross-check where available"",""metadata_sources"":[""UniProt"",""PubMed"",""EuropePMC""],""fulltext_reviewed"":false}]"
LXL04_022502	gene-LXL04_022502	KAL4575651.1	OH-1004	2	Q0DXS3	RDR1_ORYSJ	Swiss-Prot		Probable RNA-dependent RNA polymerase 1 OS=Oryza sativa subsp. japonica OX=39947 GN=RDR1 PE=2 SV=2	Oryza sativa subsp. japonica	RDR1	65.612	727	65.339	0.0	983.0	moderate_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	Os02g0736200	可能参与RNA沉默途径，并且对小干扰RNA（siRNA）的生成是必需的。	Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).	[]
LXL04_022502	gene-LXL04_022502	KAL4575651.1	OH-1004	4	Q7XM31	RDR2_ORYSJ	Swiss-Prot		Probable RNA-dependent RNA polymerase 2 OS=Oryza sativa subsp. japonica OX=39947 GN=RDR2 PE=2 SV=1	Oryza sativa subsp. japonica	RDR2	39.982	1088	94.48	0.0	733.0	moderate_database_homology	BLASTP to reviewed UniProt Swiss-Prot	UniProt Swiss-Prot current_release 2026-06-10	Os04g0465700	可能参与RNA沉默途径，并且对小干扰RNA（siRNA）的生成是必需的。	Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).	[]