query	gene_id	record_type	id	name	namespace_or_position	evidence	source	query_reference	annotation_reference	annotation_gene_id	annotation_assembly	mapping_category	mapped_annotation
TkA05G411400	TkA05G411400	function	TkA05G411400	Similar to WRKY41: Probable WRKY transcription factor 41 (Arabidopsis thaliana OX%3D3702)		GFF-derived	GCA_047496595.1_OSU_TarKok_2.0	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0006351	DNA-templated transcription	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=39.409; coverage=60.059; evalue=2.07e-34; UniProt GO evidence=IEA:UniProtKB-KW	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0006355	regulation of DNA-templated transcription	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=36.41; coverage=57.692; evalue=1.88e-28; UniProt GO evidence=IMP:TAIR	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0006952	defense response	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=5; identity=38.333; coverage=53.254; evalue=7.88e-28; UniProt GO evidence=IEA:UniProtKB-KW	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0009409	response to cold	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=39.409; coverage=60.059; evalue=2.07e-34; UniProt GO evidence=IMP:TAIR	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0009617	response to bacterium	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=33.617; coverage=69.527; evalue=4.46e-31; UniProt GO evidence=IEP:UniProtKB	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0009742	brassinosteroid mediated signaling pathway	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=36.41; coverage=57.692; evalue=1.88e-28; UniProt GO evidence=IEA:UniProtKB-KW	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0009751	response to salicylic acid	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=39.409; coverage=60.059; evalue=2.07e-34; UniProt GO evidence=IEA:UniProtKB-ARBA	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0010150	leaf senescence	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=39.409; coverage=60.059; evalue=2.07e-34; UniProt GO evidence=IEA:UniProtKB-ARBA	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0010193	response to ozone	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=39.409; coverage=60.059; evalue=2.07e-34; UniProt GO evidence=IEA:UniProtKB-ARBA	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0031347	regulation of defense response	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=33.617; coverage=69.527; evalue=4.46e-31; UniProt GO evidence=IMP:TAIR	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0033198	response to ATP	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=36.41; coverage=57.692; evalue=1.88e-28; UniProt GO evidence=IEP:TAIR	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0042542	response to hydrogen peroxide	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=39.409; coverage=60.059; evalue=2.07e-34; UniProt GO evidence=IEA:UniProtKB-ARBA	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0042742	defense response to bacterium	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=2; identity=31.159; coverage=81.657; evalue=6.33e-34; UniProt GO evidence=IEP:TAIR	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0045893	positive regulation of DNA-templated transcription	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=33.617; coverage=69.527; evalue=4.46e-31; UniProt GO evidence=IDA:TAIR	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0048527	lateral root development	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=36.41; coverage=57.692; evalue=1.88e-28; UniProt GO evidence=IMP:TAIR	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0071456	cellular response to hypoxia	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=36.41; coverage=57.692; evalue=1.88e-28; UniProt GO evidence=HEP:TAIR	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:1900457	regulation of brassinosteroid mediated signaling pathway	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=36.41; coverage=57.692; evalue=1.88e-28; UniProt GO evidence=IMP:UniProtKB	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:2000022	regulation of jasmonic acid mediated signaling pathway	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=33.617; coverage=69.527; evalue=4.46e-31; UniProt GO evidence=IMP:UniProtKB	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:2000070	regulation of response to water deprivation	biological_process	Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=36.41; coverage=57.692; evalue=1.88e-28; UniProt GO evidence=IMP:UniProtKB	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0005634	nucleus	cellular_component	Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=39.409; coverage=60.059; evalue=2.07e-34; UniProt GO evidence=ISM:TAIR	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0005730	nucleolus	cellular_component	Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=36.41; coverage=57.692; evalue=1.88e-28; UniProt GO evidence=HDA:TAIR	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0005737	cytoplasm	cellular_component	Swiss-Prot reviewed homolog transfer; hit_rank=2; identity=31.159; coverage=81.657; evalue=6.33e-34; UniProt GO evidence=IDA:TAIR	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0009507	chloroplast	cellular_component	Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=33.617; coverage=69.527; evalue=4.46e-31; UniProt GO evidence=HDA:TAIR	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0000976	transcription cis-regulatory region binding	molecular_function	Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=39.409; coverage=60.059; evalue=2.07e-34; UniProt GO evidence=IBA:GO_Central	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	molecular_function	Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=33.617; coverage=69.527; evalue=4.46e-31; UniProt GO evidence=IPI:TAIR	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0000987	cis-regulatory region sequence-specific DNA binding	molecular_function	Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=36.41; coverage=57.692; evalue=1.88e-28; UniProt GO evidence=IPI:TAIR	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0003677	DNA binding	molecular_function	Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=33.617; coverage=69.527; evalue=4.46e-31; UniProt GO evidence=IDA:TAIR	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0003700	DNA-binding transcription factor activity	molecular_function	Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=39.409; coverage=60.059; evalue=2.07e-34; UniProt GO evidence=IDA:TAIR	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	GO	GO:0043565	sequence-specific DNA binding	molecular_function	Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=36.41; coverage=57.692; evalue=1.88e-28; UniProt GO evidence=IDA:TAIR	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	KEGG	ath:AT2G46400	KEGG gene cross-reference from reviewed UniProt hit; pathway name pending		Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=36.41; coverage=57.692; evalue=1.88e-28	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	KEGG	ath:AT4G11070	KEGG gene cross-reference from reviewed UniProt hit; pathway name pending		Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=39.409; coverage=60.059; evalue=2.07e-34	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	KEGG	ath:AT4G23810	KEGG gene cross-reference from reviewed UniProt hit; pathway name pending		Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=33.617; coverage=69.527; evalue=4.46e-31	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	KEGG	ath:AT5G24110	KEGG gene cross-reference from reviewed UniProt hit; pathway name pending		Swiss-Prot reviewed homolog transfer; hit_rank=2; identity=31.159; coverage=81.657; evalue=6.33e-34	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	KEGG	dosa:Os05g0571200	KEGG gene cross-reference from reviewed UniProt hit; pathway name pending		Swiss-Prot reviewed homolog transfer; hit_rank=5; identity=38.333; coverage=53.254; evalue=7.88e-28	UniProtKB/Swiss-Prot DAT 2026 current_release	TK1151	OH1004	LXL04_021616	GCA_047496595.1_OSU_TarKok_2.0	many_to_one	True
TkA05G411400	TkA05G411400	organism_homology	Q8H0Y8	sp|Q8H0Y8|WRK41_ARATH Probable WRKY transcription factor 41	Arabidopsis thaliana	identity=40.4; coverage=56.805; evalue=1.16e-31; rank=1	TK1151 Swiss-Prot homology; source_gene=TkA05G411400; source_db=UniProt Swiss-Prot local database (DIAMOND)	TK1151	TK1151	TkA05G411400			False
TkA05G411400	TkA05G411400	organism_homology	Q0DFT7	sp|Q0DFT7|WRK19_ORYSJ Transcription factor WRKY19	Oryza sativa subsp. japonica	identity=56.5; coverage=25.148; evalue=4.13e-25; rank=4	TK1151 Swiss-Prot homology; source_gene=TkA05G411400; source_db=UniProt Swiss-Prot local database (DIAMOND)	TK1151	TK1151	TkA05G411400			False
TkA05G411400	TkA05G411400	reference_gene_function	At4g11070	转录因子。	Arabidopsis	暂无已核实直接文献							
TkA05G411400	TkA05G411400	reference_gene_literature	At4g23810	转录因子。	Arabidopsis	The antagonist function of Arabidopsis WRKY53 and ESR/ESP in leaf senescence is modulated by the jasmonic and salicylic acid equilibrium.; PMID=17369373; DOI=10.1105/tpc.106.042705	https://pubmed.ncbi.nlm.nih.gov/17369373/						
TkA05G411400	TkA05G411400	reference_gene_literature	At4g23810	转录因子。	Arabidopsis	A HECT E3 ubiquitin ligase negatively regulates Arabidopsis leaf senescence through degradation of the transcription factor WRKY53.; PMID=20409006; DOI=10.1111/j.1365-313x.2010.04233.x	https://pubmed.ncbi.nlm.nih.gov/20409006/						
TkA05G411400	TkA05G411400	reference_gene_literature	At4g23810	转录因子。	Arabidopsis	Arabidopsis WRKY46 coordinates with WRKY70 and WRKY53 in basal resistance against pathogen Pseudomonas syringae.; PMID=22325892; DOI=10.1016/j.plantsci.2011.12.003	https://pubmed.ncbi.nlm.nih.gov/22325892/						
TkA05G411400	TkA05G411400	reference_gene_function	At5g24110	转录因子。	Arabidopsis	暂无已核实直接文献							
TkA05G411400	TkA05G411400	reference_gene_literature	At3g56400	通过调节各种植物激素信号通路参与衰老、以及生物和非生物胁迫反应的转录因子。	Arabidopsis	WRKY70 modulates the selection of signaling pathways in plant defense.; PMID=16623907; DOI=10.1111/j.1365-313x.2006.02712.x	https://pubmed.ncbi.nlm.nih.gov/16623907/						
TkA05G411400	TkA05G411400	reference_gene_literature	At3g56400	通过调节各种植物激素信号通路参与衰老、以及生物和非生物胁迫反应的转录因子。	Arabidopsis	The WRKY70 transcription factor of Arabidopsis influences both the plant senescence and defense signaling pathways.; PMID=17310369; DOI=10.1007/s00425-006-0474-y	https://pubmed.ncbi.nlm.nih.gov/17310369/						
TkA05G411400	TkA05G411400	reference_gene_literature	At3g56400	通过调节各种植物激素信号通路参与衰老、以及生物和非生物胁迫反应的转录因子。	Arabidopsis	Arabidopsis WRKY70 is required for full RPP4-mediated disease resistance and basal defense against Hyaloperonospora parasitica.; PMID=17313163; DOI=10.1094/mpmi-20-2-0120	https://pubmed.ncbi.nlm.nih.gov/17313163/						
TkA05G411400	TkA05G411400	reference_gene_literature	At3g56400	通过调节各种植物激素信号通路参与衰老、以及生物和非生物胁迫反应的转录因子。	Arabidopsis	Transcription factor WRKY70 displays important but no indispensable roles in jasmonate and salicylic acid signaling.; PMID=18713432; DOI=10.1111/j.1744-7909.2008.00653.x	https://pubmed.ncbi.nlm.nih.gov/18713432/						
TkA05G411400	TkA05G411400	reference_gene_literature	At3g56400	通过调节各种植物激素信号通路参与衰老、以及生物和非生物胁迫反应的转录因子。	Arabidopsis	WRKY54 and WRKY70 co-operate as negative regulators of leaf senescence in Arabidopsis thaliana.; PMID=22268143; DOI=10.1093/jxb/err450	https://pubmed.ncbi.nlm.nih.gov/22268143/						
TkA05G411400	TkA05G411400	reference_gene_literature	At3g56400	通过调节各种植物激素信号通路参与衰老、以及生物和非生物胁迫反应的转录因子。	Arabidopsis	EDS1 contributes to nonhost resistance of Arabidopsis thaliana against Erwinia amylovora.; PMID=22316300; DOI=10.1094/mpmi-05-11-0111	https://pubmed.ncbi.nlm.nih.gov/22316300/						
TkA05G411400	TkA05G411400	reference_gene_literature	At3g56400	通过调节各种植物激素信号通路参与衰老、以及生物和非生物胁迫反应的转录因子。	Arabidopsis	Arabidopsis WRKY46 coordinates with WRKY70 and WRKY53 in basal resistance against pathogen Pseudomonas syringae.; PMID=22325892; DOI=10.1016/j.plantsci.2011.12.003	https://pubmed.ncbi.nlm.nih.gov/22325892/						
TkA05G411400	TkA05G411400	reference_gene_literature	At3g56400	通过调节各种植物激素信号通路参与衰老、以及生物和非生物胁迫反应的转录因子。	Arabidopsis	Defense-related transcription factors WRKY70 and WRKY54 modulate osmotic stress tolerance by regulating stomatal aperture in Arabidopsis.; PMID=23815736; DOI=10.1111/nph.12378	https://pubmed.ncbi.nlm.nih.gov/23815736/						
TkA05G411400	TkA05G411400	reference_gene_literature	At3g56400	通过调节各种植物激素信号通路参与衰老、以及生物和非生物胁迫反应的转录因子。	Arabidopsis	Identification of a novel type of WRKY transcription factor binding site in elicitor-responsive cis-sequences from Arabidopsis thaliana.; PMID=24104863; DOI=10.1007/s11103-013-0136-y	https://pubmed.ncbi.nlm.nih.gov/24104863/						
TkA05G411400	TkA05G411400	reference_gene_literature	At3g56400	通过调节各种植物激素信号通路参与衰老、以及生物和非生物胁迫反应的转录因子。	Arabidopsis	Density-dependent interference of aphids with caterpillar-induced defenses in Arabidopsis: involvement of phytohormones and transcription factors.; PMID=25339349; DOI=10.1093/pcp/pcu150	https://pubmed.ncbi.nlm.nih.gov/25339349/						
TkA05G411400	TkA05G411400	reference_gene_literature	At3g56400	通过调节各种植物激素信号通路参与衰老、以及生物和非生物胁迫反应的转录因子。	Arabidopsis	Transcription factors WRKY70 and WRKY11 served as regulators in rhizobacterium Bacillus cereus AR156-induced systemic resistance to Pseudomonas syringae pv. tomato DC3000 in Arabidopsis.; PMID=26433201; DOI=10.1093/jxb/erv445	https://pubmed.ncbi.nlm.nih.gov/26433201/						
TkA05G411400	TkA05G411400	reference_gene_literature	At3g56400	通过调节各种植物激素信号通路参与衰老、以及生物和非生物胁迫反应的转录因子。	Arabidopsis	Arabidopsis WRKY46, WRKY54, and WRKY70 Transcription Factors Are Involved in Brassinosteroid-Regulated Plant Growth and Drought Responses.; PMID=28576847; DOI=10.1105/tpc.17.00364	https://pubmed.ncbi.nlm.nih.gov/28576847/						
TkA05G411400	TkA05G411400	reference_gene_literature	At3g56400	通过调节各种植物激素信号通路参与衰老、以及生物和非生物胁迫反应的转录因子。	Arabidopsis	WRKY70 and its homolog WRKY54 negatively modulate the cell wall-associated defenses to necrotrophic pathogens in Arabidopsis.; PMID=28837631; DOI=10.1371/journal.pone.0183731	https://pubmed.ncbi.nlm.nih.gov/28837631/						
TkA05G411400	TkA05G411400	reference_gene_literature	Os05g0571200	可能在防御反应中发挥作用。	Rice	The bHLH Rac Immunity1 (RAI1) Is Activated by OsRac1 via OsMAPK3 and OsMAPK6 in Rice Immunity.; PMID=22437844; DOI=10.1093/pcp/pcs033	https://pubmed.ncbi.nlm.nih.gov/22437844/						
