query gene_id record_type id name namespace_or_position evidence source query_reference annotation_reference annotation_gene_id annotation_assembly mapping_category mapped_annotation LXL04_017609 LXL04_017609 function LXL04_017609 Similar to EDM2: Protein ENHANCED DOWNY MILDEW 2 (Arabidopsis thaliana OX%3D3702) GFF-derived GCA_047496595.1_OSU_TarKok_2.0 OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0006338 chromatin remodeling biological_process Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=31.288; coverage=15.856; evalue=2e-14; UniProt GO evidence=IEA:UniProtKB-ARBA UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0006351 DNA-templated transcription biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IEA:UniProtKB-KW UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0006355 regulation of DNA-templated transcription biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0007165 signal transduction biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IMP:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0009911 positive regulation of flower development biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0010228 vegetative to reproductive phase transition of meristem biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0010440 stomatal lineage progression biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0031347 regulation of defense response biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0031452 negative regulation of heterochromatin formation biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0032259 methylation biological_process Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=32.919; coverage=15.661; evalue=1.22e-14; UniProt GO evidence=IEA:UniProtKB-KW UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0040029 epigenetic regulation of gene expression biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IDA:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0045892 negative regulation of DNA-templated transcription biological_process Swiss-Prot reviewed homolog transfer; hit_rank=5; identity=33.129; coverage=15.856; evalue=5.25e-13; UniProt GO evidence=IDA:MGI UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0045893 positive regulation of DNA-templated transcription biological_process Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=32.919; coverage=15.661; evalue=1.22e-14; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0050832 defense response to fungus biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IMP:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0060147 regulation of post-transcriptional gene silencing biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0090436 leaf pavement cell development biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0141005 transposable element silencing by heterochromatin formation biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IDA:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:1902290 positive regulation of defense response to oomycetes biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:2000024 regulation of leaf development biological_process Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0000785 chromatin cellular_component Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=32.919; coverage=15.661; evalue=1.22e-14; UniProt GO evidence=IBA:GO_Central UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0000792 heterochromatin cellular_component Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0005634 nucleus cellular_component Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IDA:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0005654 nucleoplasm cellular_component Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=32.919; coverage=15.661; evalue=1.22e-14; UniProt GO evidence=IDA:HPA UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0032991 protein-containing complex cellular_component Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IPI:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0003700 DNA-binding transcription factor activity molecular_function Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=ISS:TAIR UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0008270 zinc ion binding molecular_function Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IEA:UniProtKB-KW UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0042800 histone H3K4 methyltransferase activity molecular_function Swiss-Prot reviewed homolog transfer; hit_rank=5; identity=33.129; coverage=15.856; evalue=5.25e-13; UniProt GO evidence=IDA:MGI UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0043565 sequence-specific DNA binding molecular_function Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IDA:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0046975 histone H3K36 methyltransferase activity molecular_function Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=32.919; coverage=15.661; evalue=1.22e-14; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0046976 histone H3K27 methyltransferase activity molecular_function Swiss-Prot reviewed homolog transfer; hit_rank=5; identity=33.129; coverage=15.856; evalue=5.25e-13; UniProt GO evidence=IDA:MGI UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0062072 histone H3K9me2/3 reader activity molecular_function Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IDA:GO_Central UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0140537 transcription regulator activator activity molecular_function Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=32.919; coverage=15.661; evalue=1.22e-14; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0140566 histone reader activity molecular_function Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119; UniProt GO evidence=IMP:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0140938 histone H3 methyltransferase activity molecular_function Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=32.919; coverage=15.661; evalue=1.22e-14; UniProt GO evidence=TAS:Reactome UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0140946 histone H3K4 dimethyltransferase activity molecular_function Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=32.919; coverage=15.661; evalue=1.22e-14; UniProt GO evidence=IDA:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0140951 histone H3K27 trimethyltransferase activity molecular_function Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=32.919; coverage=15.661; evalue=1.22e-14; UniProt GO evidence=IDA:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 GO GO:0140952 histone H3K27 dimethyltransferase activity molecular_function Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=32.919; coverage=15.661; evalue=1.22e-14; UniProt GO evidence=IDA:UniProtKB UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 KEGG ath:AT5G55390 KEGG gene cross-reference from reviewed UniProt hit; pathway name pending Swiss-Prot reviewed homolog transfer; hit_rank=1; identity=60.0; coverage=30.156; evalue=2.34e-119 UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 KEGG ddi:DDB_G0268158 KEGG gene cross-reference from reviewed UniProt hit; pathway name pending Swiss-Prot reviewed homolog transfer; hit_rank=4; identity=31.288; coverage=15.856; evalue=2e-14 UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 KEGG hsa:54904 KEGG gene cross-reference from reviewed UniProt hit; pathway name pending Swiss-Prot reviewed homolog transfer; hit_rank=3; identity=32.919; coverage=15.661; evalue=1.22e-14 UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 KEGG mmu:234135 KEGG gene cross-reference from reviewed UniProt hit; pathway name pending Swiss-Prot reviewed homolog transfer; hit_rank=5; identity=33.129; coverage=15.856; evalue=5.25e-13 UniProtKB/Swiss-Prot DAT 2026 current_release OH1004 OH1004 LXL04_017609 GCA_047496595.1_OSU_TarKok_2.0 strict_1to1 False LXL04_017609 LXL04_017609 organism_homology F4K3G5 Protein ENHANCED DOWNY MILDEW 2 OS=Arabidopsis thaliana OX=3702 GN=EDM2 PE=1 SV=1 Arabidopsis thaliana identity=60.0; coverage=30.156; evalue=2.34e-119; rank=1 OH-1004 Swiss-Prot homology; source_gene=LXL04_017609; source_db=UniProt Swiss-Prot current_release 2026-06-10 OH1004 OH1004 LXL04_017609 False LXL04_017609 LXL04_017609 organism_homology_status Oryza sativa 当前查询蛋白的来源表暂无该物种命中；不能据此判断不存在同源。 no_species_hit OH1004 OH1004 LXL04_017609 False LXL04_017609 LXL04_017609 reference_gene_literature At5g55390 Cellular antisilencing factor and regulator of genome DNA methylation patterns involved in the regulation of chromatin states. Arabidopsis EDM2 is required for RPP7-dependent disease resistance in Arabidopsis and affects RPP7 transcript levels.; PMID=17253987; DOI=10.1111/j.1365-313x.2006.02999.x https://pubmed.ncbi.nlm.nih.gov/17253987/ LXL04_017609 LXL04_017609 reference_gene_literature At5g55390 Cellular antisilencing factor and regulator of genome DNA methylation patterns involved in the regulation of chromatin states. Arabidopsis The Arabidopsis defense component EDM2 affects the floral transition in an FLC-dependent manner.; PMID=20149132; DOI=10.1111/j.1365-313x.2010.04169.x https://pubmed.ncbi.nlm.nih.gov/20149132/ LXL04_017609 LXL04_017609 reference_gene_literature At5g55390 Cellular antisilencing factor and regulator of genome DNA methylation patterns involved in the regulation of chromatin states. Arabidopsis Co-option of EDM2 to distinct regulatory modules in Arabidopsis thaliana development.; PMID=20840782; DOI=10.1186/1471-2229-10-203 https://pubmed.ncbi.nlm.nih.gov/20840782/ LXL04_017609 LXL04_017609 reference_gene_literature At5g55390 Cellular antisilencing factor and regulator of genome DNA methylation patterns involved in the regulation of chromatin states. Arabidopsis EMSY-like genes are required for full RPP7-mediated race-specific immunity and basal defense in Arabidopsis.; PMID=21830950; DOI=10.1094/mpmi-05-11-0123 https://pubmed.ncbi.nlm.nih.gov/21830950/ LXL04_017609 LXL04_017609 reference_gene_literature At5g55390 Cellular antisilencing factor and regulator of genome DNA methylation patterns involved in the regulation of chromatin states. Arabidopsis Mutations in EDM2 selectively affect silencing states of transposons and induce plant developmental plasticity.; PMID=23609044; DOI=10.1038/srep01701 https://pubmed.ncbi.nlm.nih.gov/23609044/ LXL04_017609 LXL04_017609 reference_gene_literature At5g55390 Cellular antisilencing factor and regulator of genome DNA methylation patterns involved in the regulation of chromatin states. Arabidopsis Antagonistic regulation of flowering time through distinct regulatory subunits of protein phosphatase 2A.; PMID=23976921; DOI=10.1371/journal.pone.0067987 https://pubmed.ncbi.nlm.nih.gov/23976921/ LXL04_017609 LXL04_017609 reference_gene_literature At5g55390 Cellular antisilencing factor and regulator of genome DNA methylation patterns involved in the regulation of chromatin states. Arabidopsis Arabidopsis EDM2 promotes IBM1 distal polyadenylation and regulates genome DNA methylation patterns.; PMID=24248388; DOI=10.1073/pnas.1320106110 https://pubmed.ncbi.nlm.nih.gov/24248388/ LXL04_017609 LXL04_017609 reference_gene_literature At5g55390 Cellular antisilencing factor and regulator of genome DNA methylation patterns involved in the regulation of chromatin states. Arabidopsis Demethylation of ERECTA receptor genes by IBM1 histone demethylase affects stomatal development.; PMID=27697902; DOI=10.1242/dev.129932 https://pubmed.ncbi.nlm.nih.gov/27697902/ LXL04_017609 LXL04_017609 reference_gene_literature At5g55390 Cellular antisilencing factor and regulator of genome DNA methylation patterns involved in the regulation of chromatin states. Arabidopsis A protein complex regulates RNA processing of intronic heterochromatin-containing genes in Arabidopsis .; PMID=28808009; DOI=10.1073/pnas.1710683114 https://pubmed.ncbi.nlm.nih.gov/28808009/ LXL04_017609 LXL04_017609 reference_gene_literature At5g55390 Cellular antisilencing factor and regulator of genome DNA methylation patterns involved in the regulation of chromatin states. Arabidopsis The Arabidopsis RRM domain protein EDM3 mediates race-specific disease resistance by controlling H3K9me2-dependent alternative polyadenylation of RPP7 immune receptor transcripts.; PMID=30407670; DOI=10.1111/tpj.14148 https://pubmed.ncbi.nlm.nih.gov/30407670/ LXL04_017609 LXL04_017609 reference_gene_literature At5g55390 Cellular antisilencing factor and regulator of genome DNA methylation patterns involved in the regulation of chromatin states. Arabidopsis The Arabidopsis PHD-finger protein EDM2 has multiple roles in balancing NLR immune receptor gene expression.; PMID=32925902; DOI=10.1371/journal.pgen.1008993 https://pubmed.ncbi.nlm.nih.gov/32925902/ LXL04_017609 LXL04_017609 reference_gene_literature At5g55390 Cellular antisilencing factor and regulator of genome DNA methylation patterns involved in the regulation of chromatin states. Arabidopsis Genome-wide distribution and functions of the AAE complex in epigenetic regulation in Arabidopsis.; PMID=33438356; DOI=10.1111/jipb.13068 https://pubmed.ncbi.nlm.nih.gov/33438356/