Species	Reference gene ID	Possible function	Papers / DOI
Arabidopsis	At5g02820	Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles.	A crucial role for the putative Arabidopsis topoisomerase VI in plant growth and development.; 2002; DOI: 10.1073/pnas.152337599; PMID: 12119417; https://pubmed.ncbi.nlm.nih.gov/12119417/ | DNA topoisomerase VI is essential for endoreduplication in Arabidopsis.; 2002; DOI: 10.1016/s0960-9822(02)01198-3; PMID: 12401175; https://pubmed.ncbi.nlm.nih.gov/12401175/
Arabidopsis	At3g13170	DNA endonuclease, which specifically mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination.	AtSPO11-1 is necessary for efficient meiotic recombination in plants.; 2001; DOI: 10.1093/emboj/20.3.589; PMID: 11157765; https://pubmed.ncbi.nlm.nih.gov/11157765/ | Arabidopsis SPO11-2 functions with SPO11-1 in meiotic recombination.; 2006; DOI: 10.1111/j.1365-313x.2006.02867.x; PMID: 17018031; https://pubmed.ncbi.nlm.nih.gov/17018031/ | The catalytically active tyrosine residues of both SPO11-1 and SPO11-2 are required for meiotic double-strand break induction in Arabidopsis.; 2007; DOI: 10.1105/tpc.107.054817; PMID: 17965269; https://pubmed.ncbi.nlm.nih.gov/17965269/ | A high throughput genetic screen identifies new early meiotic recombination functions in Arabidopsis thaliana.; 2009; DOI: 10.1371/journal.pgen.1000654; PMID: 19763177; https://pubmed.ncbi.nlm.nih.gov/19763177/ | A DNA topoisomerase VI-like complex initiates meiotic recombination.; 2016; DOI: 10.1126/science.aad5196; PMID: 26917763; https://pubmed.ncbi.nlm.nih.gov/26917763/
Rice	UniProt: A2XFC1	Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles.	No verified direct reference in this release
Rice	Os03g0284800	Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles.	No verified direct reference in this release